eF-site/Summary 6xaa-AB

eF-site ID	6xaa-AB
PDB Code	6xaa
Chain	A, B

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Title	SARS CoV-2 PLpro in complex with ubiquitin propargylamide
Classification	HYDROLASE/SUBSTRATE
Compound	Non-structural protein 3
Source	(J3QS39_HUMAN)

Sequence	A:	IKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKI KPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYM SALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIE LKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGD VRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEA VMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMM SAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYC IDGALLTKSSEYKGPITDVFYKENSYTTT
	B:	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGX

Description

Functional site


1)	chain	A
	residue	189
	type
	sequence	C
	description	binding site for residue ZN A 501
	source	: AC1

2)	chain	A
	residue	192
	type
	sequence	C
	description	binding site for residue ZN A 501
	source	: AC1

3)	chain	A
	residue	224
	type
	sequence	C
	description	binding site for residue ZN A 501
	source	: AC1

4)	chain	A
	residue	226
	type
	sequence	C
	description	binding site for residue ZN A 501
	source	: AC1

5)	chain	A
	residue	189
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00444
	source	Swiss-Prot : SWS_FT_FI4

6)	chain	A
	residue	192
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00444
	source	Swiss-Prot : SWS_FT_FI4

7)	chain	A
	residue	224
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00444
	source	Swiss-Prot : SWS_FT_FI4

8)	chain	A
	residue	226
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00444
	source	Swiss-Prot : SWS_FT_FI4

9)	chain	B
	residue	27-52
	type	prosite
	sequence	KAKIQDKEGIPPDQQRLIFAGKQLED
	description	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
	source	prosite : PS00299

10)	chain	A
	residue	189-226
	type	ZN_FING
	sequence	CKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTC
	description	C4-type => ECO:0000255\|PROSITE-ProRule:PRU00444
	source	Swiss-Prot : SWS_FT_FI1

11)	chain	A
	residue	111
	type	ACT_SITE
	sequence	C
	description	For PL-PRO activity => ECO:0000255\|PROSITE-ProRule:PRU00444, ECO:0000269\|PubMed:32726803
	source	Swiss-Prot : SWS_FT_FI2

12)	chain	A
	residue	286
	type	ACT_SITE
	sequence	D
	description	For PL-PRO activity => ECO:0000255\|PROSITE-ProRule:PRU00444
	source	Swiss-Prot : SWS_FT_FI3

13)	chain	A
	residue	272
	type	ACT_SITE
	sequence	H
	description	For PL-PRO activity => ECO:0000255\|PROSITE-ProRule:PRU00444
	source	Swiss-Prot : SWS_FT_FI3