eF-site ID 6vww-B PDB Code 6vww Chain B click to enlarge Title Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2. Classification VIRAL PROTEIN Compound Uridylate-specific endoribonuclease Source (R1AB_SARS2) Sequence B:  NMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGV DVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVD IAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAP LTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPK QASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSR NLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYG DFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNY FITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVV KVTIDYTEISFMLWCKDGHVETFYPKLQ Description Functional site 1) chain B residue 75 type sequence N description binding site for residue GOL B 401 source : AC7 2) chain B residue 274 type sequence S description binding site for residue GOL B 401 source : AC7 3) chain B residue 275 type sequence T description binding site for residue GOL B 401 source : AC7 4) chain B residue 276 type sequence V description binding site for residue GOL B 401 source : AC7 5) chain B residue 90 type sequence K description binding site for residue GOL B 402 source : AC8 6) chain B residue 167 type sequence T description binding site for residue GOL B 402 source : AC8 7) chain B residue 198 type sequence S description binding site for residue GOL B 402 source : AC8 8) chain B residue 199 type sequence R description binding site for residue GOL B 402 source : AC8 9) chain B residue 200 type sequence N description binding site for residue GOL B 402 source : AC8 10) chain B residue 77 type sequence G description binding site for residue GOL B 403 source : AC9 11) chain B residue 79 type sequence D description binding site for residue GOL B 403 source : AC9 12) chain B residue 119 type sequence P description binding site for residue GOL B 403 source : AC9 13) chain B residue 121 type sequence T description binding site for residue GOL B 403 source : AC9 14) chain B residue 149 type sequence V description binding site for residue CL B 404 source : AD1 15) chain B residue 151 type sequence G description binding site for residue CL B 404 source : AD1 16) chain B residue 43 type sequence L description binding site for residue GOL B 405 source : AD2 17) chain B residue 44 type sequence F description binding site for residue GOL B 405 source : AD2 18) chain B residue 45 type sequence E description binding site for residue GOL B 405 source : AD2 19) chain B residue 59 type sequence W description binding site for residue GOL B 405 source : AD2 20) chain B residue 192 type sequence E description binding site for residue GOL B 406 source : AD3 21) chain B residue 320 type sequence K description binding site for residue GOL B 406 source : AD3 22) chain B residue 322 type sequence T description binding site for residue GOL B 406 source : AD3 23) chain B residue 327 type sequence E description binding site for residue GOL B 406 source : AD3 24) chain B residue 146 type sequence E description binding site for residue ACY B 407 source : AD4 25) chain B residue 174 type sequence K description binding site for residue ACY B 407 source : AD4 26) chain B residue 176 type sequence Q description binding site for residue ACY B 407 source : AD4 27) chain B residue 177 type sequence F description binding site for residue ACY B 407 source : AD4 28) chain B residue 178 type sequence N description binding site for residue ACY B 407 source : AD4 29) chain B residue 312 type sequence L description binding site for residue ACY B 408 source : AD5 30) chain B residue 313 type sequence S description binding site for residue ACY B 408 source : AD5 31) chain B residue 314 type sequence V description binding site for residue ACY B 408 source : AD5 32) chain B residue 315 type sequence V description binding site for residue ACY B 408 source : AD5 33) chain B residue 334 type sequence C description binding site for residue ACY B 408 source : AD5 34) chain B residue 335 type sequence K description binding site for residue ACY B 408 source : AD5 35) chain B residue 336 type sequence D description binding site for residue ACY B 408 source : AD5 36) chain B residue 337 type sequence G description binding site for residue ACY B 408 source : AD5 37) chain B residue 290 type BINDING sequence K description BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 source Swiss-Prot : SWS_FT_FI4 38) chain B residue 235 type ACT_SITE sequence H description Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 250 type ACT_SITE sequence H description Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 290 type ACT_SITE sequence K description For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 341 type BINDING sequence T description BINDING => ECO:0000269|PubMed:33564093 source Swiss-Prot : SWS_FT_FI5 42) chain B residue 290 type SITE sequence K description Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 source Swiss-Prot : SWS_FT_FI6 43) chain B residue 294 type SITE sequence S description Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 source Swiss-Prot : SWS_FT_FI7 44) chain B residue 347 type SITE sequence Q description Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 source Swiss-Prot : SWS_FT_FI8

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