eF-site ID 6vo2-AB PDB Code 6vo2 Chain A, B click to enlarge Title Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg, NADPH and inhibitor. Classification METAL BINDING PROTEIN Compound Ketol-acid reductoisomerase (NADP(+)) Source (A0A145BYP4_STAAU) Sequence A:  TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGY DVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLP DEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPAD VDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQAR NIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGG VSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEG GMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDI QNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGRELR EMMPFI B:  TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGY DVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLP DEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPAD VDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQAR NIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGG VSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEG GMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDI QNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGRELR EMMPFI Description Functional site 1) chain A residue 190 type sequence D description binding site for residue MG A 401 source : AC1 2) chain A residue 194 type sequence E description binding site for residue MG A 401 source : AC1 3) chain A residue 190 type sequence D description binding site for residue MG A 402 source : AC2 4) chain A residue 230 type sequence E description binding site for residue R67 A 403 source : AC3 5) chain A residue 234 type sequence I description binding site for residue R67 A 403 source : AC3 6) chain A residue 250 type sequence I description binding site for residue R67 A 403 source : AC3 7) chain A residue 251 type sequence S description binding site for residue R67 A 403 source : AC3 8) chain A residue 254 type sequence A description binding site for residue R67 A 403 source : AC3 9) chain B residue 131 type sequence G description binding site for residue R67 A 403 source : AC3 10) chain B residue 132 type sequence P description binding site for residue R67 A 403 source : AC3 11) chain B residue 190 type sequence D description binding site for residue R67 A 403 source : AC3 12) chain B residue 194 type sequence E description binding site for residue R67 A 403 source : AC3 13) chain A residue 25 type sequence Y description binding site for residue NDP A 404 source : AC4 14) chain A residue 26 type sequence G description binding site for residue NDP A 404 source : AC4 15) chain A residue 27 type sequence S description binding site for residue NDP A 404 source : AC4 16) chain A residue 28 type sequence Q description binding site for residue NDP A 404 source : AC4 17) chain A residue 47 type sequence I description binding site for residue NDP A 404 source : AC4 18) chain A residue 48 type sequence R description binding site for residue NDP A 404 source : AC4 19) chain A residue 52 type sequence S description binding site for residue NDP A 404 source : AC4 20) chain A residue 79 type sequence L description binding site for residue NDP A 404 source : AC4 21) chain A residue 80 type sequence L description binding site for residue NDP A 404 source : AC4 22) chain A residue 81 type sequence P description binding site for residue NDP A 404 source : AC4 23) chain A residue 82 type sequence D description binding site for residue NDP A 404 source : AC4 24) chain A residue 85 type sequence Q description binding site for residue NDP A 404 source : AC4 25) chain A residue 88 type sequence V description binding site for residue NDP A 404 source : AC4 26) chain A residue 106 type sequence A description binding site for residue NDP A 404 source : AC4 27) chain A residue 107 type sequence H description binding site for residue NDP A 404 source : AC4 28) chain A residue 131 type sequence G description binding site for residue NDP A 404 source : AC4 29) chain A residue 132 type sequence P description binding site for residue NDP A 404 source : AC4 30) chain A residue 133 type sequence G description binding site for residue NDP A 404 source : AC4 31) chain B residue 249 type sequence S description binding site for residue NDP A 404 source : AC4 32) chain B residue 250 type sequence I description binding site for residue NDP A 404 source : AC4 33) chain B residue 251 type sequence S description binding site for residue NDP A 404 source : AC4 34) chain B residue 190 type sequence D description binding site for residue MG B 401 source : AC5 35) chain B residue 190 type sequence D description binding site for residue MG B 402 source : AC6 36) chain B residue 194 type sequence E description binding site for residue MG B 402 source : AC6 37) chain A residue 131 type sequence G description binding site for residue R67 B 403 source : AC7 38) chain A residue 132 type sequence P description binding site for residue R67 B 403 source : AC7 39) chain A residue 190 type sequence D description binding site for residue R67 B 403 source : AC7 40) chain A residue 194 type sequence E description binding site for residue R67 B 403 source : AC7 41) chain B residue 230 type sequence E description binding site for residue R67 B 403 source : AC7 42) chain B residue 250 type sequence I description binding site for residue R67 B 403 source : AC7 43) chain B residue 251 type sequence S description binding site for residue R67 B 403 source : AC7 44) chain B residue 254 type sequence A description binding site for residue R67 B 403 source : AC7 45) chain A residue 249 type sequence S description binding site for residue NDP B 404 source : AC8 46) chain A residue 250 type sequence I description binding site for residue NDP B 404 source : AC8 47) chain A residue 251 type sequence S description binding site for residue NDP B 404 source : AC8 48) chain B residue 25 type sequence Y description binding site for residue NDP B 404 source : AC8 49) chain B residue 26 type sequence G description binding site for residue NDP B 404 source : AC8 50) chain B residue 27 type sequence S description binding site for residue NDP B 404 source : AC8 51) chain B residue 28 type sequence Q description binding site for residue NDP B 404 source : AC8 52) chain B residue 47 type sequence I description binding site for residue NDP B 404 source : AC8 53) chain B residue 48 type sequence R description binding site for residue NDP B 404 source : AC8 54) chain B residue 52 type sequence S description binding site for residue NDP B 404 source : AC8 55) chain B residue 79 type sequence L description binding site for residue NDP B 404 source : AC8 56) chain B residue 80 type sequence L description binding site for residue NDP B 404 source : AC8 57) chain B residue 81 type sequence P description binding site for residue NDP B 404 source : AC8 58) chain B residue 82 type sequence D description binding site for residue NDP B 404 source : AC8 59) chain B residue 85 type sequence Q description binding site for residue NDP B 404 source : AC8 60) chain B residue 88 type sequence V description binding site for residue NDP B 404 source : AC8 61) chain B residue 106 type sequence A description binding site for residue NDP B 404 source : AC8 62) chain B residue 107 type sequence H description binding site for residue NDP B 404 source : AC8 63) chain B residue 132 type sequence P description binding site for residue NDP B 404 source : AC8 64) chain B residue 133 type sequence G description binding site for residue NDP B 404 source : AC8 65) chain A residue 107 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 107 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI1 67) chain A residue 251 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 68) chain B residue 25 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 69) chain B residue 48 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 70) chain B residue 52 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 71) chain B residue 82 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 72) chain B residue 133 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 73) chain B residue 190 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 74) chain B residue 194 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 75) chain B residue 226 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 76) chain B residue 230 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 77) chain B residue 251 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 78) chain A residue 52 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 79) chain A residue 82 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 80) chain A residue 133 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 81) chain A residue 190 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 82) chain A residue 194 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 83) chain A residue 226 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 84) chain A residue 230 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 85) chain A residue 25 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2 86) chain A residue 48 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00435 source Swiss-Prot : SWS_FT_FI2

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