eF-site ID 6uoj-B PDB Code 6uoj Chain B click to enlarge Title Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with succinate Classification LYASE/LYASE INHIBITOR Compound Fumarate hydratase 2 Source (FUM2_LEIMA) Sequence B:  DFHFSAIFQPTDPHHHQTEFAKVEGSEKYVEEVEVFGRQA LKVNPEALTILAHRAFSDVHHFFRKDHLEGWRRAIEDPEA SDNDRYVATTLLKNACIAAGRVLPSCQDTGTAIVLGKRGE LCWTGGEDEKYLSKGIWNAYRYHNLRYSQTAALDMFKECN TGDNLPAQLDLLAVPGSDYEFLFIAKGGGSANKAYLYQET KALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAE MTMKTVKLASCRYYDSLPTTGDKYGRAFRDPEWEKIVMEV AQKSGIGAQFGGKYFAHQARVIRLPRHGASCPVGLAVSCS ADRQILAHINKSGIYIEQLEQNPAQYLPTSVKVDLKRPID KVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGE PLPEYMKTSPIYYAGPAKTPEGYASGSFGPTTAGRMDSYV DLFQSHGGSYITLAKGNRSKQVTDACKKHGGFYLGSIGGP AAILAKDSIKQVTCLAFPELGMEAVWKIEVEDFPAFIVVD DKGNDMYSKTLA Description Functional site 1) chain B residue 336 type sequence A description binding site for residue SIN A 602 source : AC2 2) chain B residue 133 type sequence C description binding site for residue SF4 B 601 source : AC3 3) chain B residue 134 type sequence Q description binding site for residue SF4 B 601 source : AC3 4) chain B residue 214 type sequence G description binding site for residue SF4 B 601 source : AC3 5) chain B residue 252 type sequence C description binding site for residue SF4 B 601 source : AC3 6) chain B residue 346 type sequence C description binding site for residue SF4 B 601 source : AC3 7) chain B residue 348 type sequence A description binding site for residue SF4 B 601 source : AC3 8) chain B residue 491 type sequence K description binding site for residue SF4 B 601 source : AC3 9) chain B residue 134 type sequence Q description binding site for residue SIN B 602 source : AC4 10) chain B residue 135 type sequence D description binding site for residue SIN B 602 source : AC4 11) chain B residue 173 type sequence R description binding site for residue SIN B 602 source : AC4 12) chain B residue 216 type sequence G description binding site for residue SIN B 602 source : AC4 13) chain B residue 421 type sequence R description binding site for residue SIN B 602 source : AC4 14) chain B residue 467 type sequence T description binding site for residue SIN B 602 source : AC4 15) chain B residue 468 type sequence T description binding site for residue SIN B 602 source : AC4 16) chain B residue 471 type sequence R description binding site for residue SIN B 602 source : AC4 17) chain B residue 491 type sequence K description binding site for residue SIN B 602 source : AC4 18) chain B residue 55 type sequence K description binding site for residue GOL B 603 source : AC5 19) chain B residue 71 type sequence N description binding site for residue GOL B 603 source : AC5 20) chain B residue 70 type sequence V description binding site for residue GOL B 604 source : AC6 21) chain B residue 72 type sequence P description binding site for residue GOL B 604 source : AC6 22) chain B residue 150 type sequence W description binding site for residue GOL B 604 source : AC6 23) chain B residue 151 type sequence T description binding site for residue GOL B 604 source : AC6 24) chain B residue 133 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 25) chain B residue 134 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 26) chain B residue 173 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 27) chain B residue 216 type BINDING sequence G description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 28) chain B residue 219 type BINDING sequence N description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 29) chain B residue 252 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 30) chain B residue 346 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 31) chain B residue 421 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 32) chain B residue 467 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 33) chain B residue 491 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1

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