eF-site ID 6u3x-B PDB Code 6u3x Chain B click to enlarge Title PCSK9 in complex with compound 2 Classification HYDROLASE Compound Proprotein convertase subtilisin/kexin type 9 Source (PCSK9_HUMAN) Sequence B:  SIPWNLERITPPRYRGGSLVEVYLLDTSIQSDHREIEGRV MVTDFENVPEEDASKCDSHGTHLAGVVSGRDAGVAKGASM RSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLL PLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSP ASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGED IIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELT LAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPS THGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSF SRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLL PQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVE DLQPNQCVGHREASIHASCCHAPGLECKVKEHGIPQEQVT VACEEGWTLTGCSALPSHVLGAYAVDNTCVVRSRAVTAVA ICCRSR Description (1)  Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-) Functional site 1) chain B residue 328 type sequence A description binding site for residue PVV B 801 source : AC1 2) chain B residue 329 type sequence S description binding site for residue PVV B 801 source : AC1 3) chain B residue 330 type sequence A description binding site for residue PVV B 801 source : AC1 4) chain B residue 331 type sequence P description binding site for residue PVV B 801 source : AC1 5) chain B residue 333 type sequence V description binding site for residue PVV B 801 source : AC1 6) chain B residue 335 type sequence T description binding site for residue PVV B 801 source : AC1 7) chain B residue 357 type sequence R description binding site for residue PVV B 801 source : AC1 8) chain B residue 358 type sequence C description binding site for residue PVV B 801 source : AC1 9) chain B residue 360 type sequence D description binding site for residue PVV B 801 source : AC1 10) chain B residue 458 type sequence R description binding site for residue PVV B 801 source : AC1 11) chain B residue 461 type sequence W description binding site for residue PVV B 801 source : AC1 12) chain B residue 476 type sequence R description binding site for residue PVV B 801 source : AC1 13) chain B residue 533 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035 source Swiss-Prot : SWS_FT_FI7 14) chain B residue 186 type ACT_SITE sequence D description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 226 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 386 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1

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