eF-site ID 6twz-.A.B.C.D.D000.E.F.G PDB Code 6twz Chain A, B, C, D, D000, E, F, G click to enlarge Title 14-3-3 sigma complexed with a phosphorylated 16E6 peptide Classification PEPTIDE BINDING PROTEIN Compound 14-3-3 protein sigma Source (6TWZ) Sequence A:  PHMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSC EERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKG PEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRV FYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDIS AAAMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTF DEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT B:  HMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCE ERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEKGPEVRE YREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKM KGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISAAAMP PTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMA DLHTLSEDSYKDSTLIMQLLRDNLTLWT C:  PHMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSC EERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGEKGPE VREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFY LKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISAA AMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDE AMADLHTLSEDSYKDSTLIMQLLRDNLTLWT D:  GPHMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELS CEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEKG PEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRV FYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDIS AAAMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTF DEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT D000:  RTRREXQL E:  RTRREXQL F:  RTRREXQL G:  RTRREXQL Description Functional site 1) chain A residue 93 type sequence Q description binding site for residue TAR A 301 source : AC1 2) chain A residue 97 type sequence D description binding site for residue TAR A 301 source : AC1 3) chain A residue 131 type sequence L description binding site for residue TAR A 301 source : AC1 4) chain A residue 139 type sequence D description binding site for residue TAR A 301 source : AC1 5) chain B residue 97 type sequence D description binding site for residue TAR B 301 source : AC2 6) chain B residue 131 type sequence L description binding site for residue TAR B 301 source : AC2 7) chain B residue 139 type sequence D description binding site for residue TAR B 301 source : AC2 8) chain B residue 143 type sequence I description binding site for residue TAR B 301 source : AC2 9) chain C residue 93 type sequence Q description binding site for residue TAR C 301 source : AC3 10) chain C residue 97 type sequence D description binding site for residue TAR C 301 source : AC3 11) chain C residue 131 type sequence L description binding site for residue TAR C 301 source : AC3 12) chain C residue 139 type sequence D description binding site for residue TAR C 301 source : AC3 13) chain D residue 97 type sequence D description binding site for residue TAR D 301 source : AC4 14) chain D residue 131 type sequence L description binding site for residue TAR D 301 source : AC4 15) chain D residue 213 type sequence Y description binding site for residue B3P D 302 source : AC5 16) chain D residue 213 type sequence Y description binding site for residue B3P D 302 source : AC5 17) chain D residue 220 type sequence M description binding site for residue B3P D 302 source : AC5 18) chain D residue 220 type sequence M description binding site for residue B3P D 302 source : AC5 19) chain D residue 221 type sequence Q description binding site for residue B3P D 302 source : AC5 20) chain D residue 221 type sequence Q description binding site for residue B3P D 302 source : AC5 21) chain A residue 56 type sequence R description binding site for Di-peptide GLU D0 155 and TPO D0 156 source : AC6 22) chain A residue 129 type sequence R description binding site for Di-peptide GLU D0 155 and TPO D0 156 source : AC6 23) chain A residue 130 type sequence Y description binding site for Di-peptide GLU D0 155 and TPO D0 156 source : AC6 24) chain A residue 175 type sequence N description binding site for Di-peptide GLU D0 155 and TPO D0 156 source : AC6 25) chain A residue 178 type sequence V description binding site for Di-peptide GLU D0 155 and TPO D0 156 source : AC6 26) chain A residue 222 type sequence L description binding site for Di-peptide GLU D0 155 and TPO D0 156 source : AC6 27) chain A residue 226 type sequence N description binding site for Di-peptide GLU D0 155 and TPO D0 156 source : AC6 28) chain A residue 56 type sequence R description binding site for Di-peptide TPO D0 156 and GLN D0 157 source : AC7 29) chain A residue 122 type sequence K description binding site for Di-peptide TPO D0 156 and GLN D0 157 source : AC7 30) chain A residue 129 type sequence R description binding site for Di-peptide TPO D0 156 and GLN D0 157 source : AC7 31) chain A residue 130 type sequence Y description binding site for Di-peptide TPO D0 156 and GLN D0 157 source : AC7 32) chain A residue 175 type sequence N description binding site for Di-peptide TPO D0 156 and GLN D0 157 source : AC7 33) chain A residue 218 type sequence L description binding site for Di-peptide TPO D0 156 and GLN D0 157 source : AC7 34) chain B residue 49 type sequence K description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 35) chain B residue 56 type sequence R description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 36) chain B residue 129 type sequence R description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 37) chain B residue 130 type sequence Y description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 38) chain B residue 175 type sequence N description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 39) chain B residue 178 type sequence V description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 40) chain B residue 222 type sequence L description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 41) chain B residue 226 type sequence N description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 42) chain E residue 154 type sequence R description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 43) chain E residue 157 type sequence Q description binding site for Di-peptide GLU E 155 and TPO E 156 source : AC8 44) chain B residue 49 type sequence K description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 45) chain B residue 56 type sequence R description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 46) chain B residue 122 type sequence K description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 47) chain B residue 129 type sequence R description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 48) chain B residue 130 type sequence Y description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 49) chain B residue 175 type sequence N description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 50) chain B residue 222 type sequence L description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 51) chain E residue 154 type sequence R description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 52) chain E residue 155 type sequence E description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 53) chain E residue 158 type sequence L description binding site for Di-peptide TPO E 156 and GLN E 157 source : AC9 54) chain C residue 56 type sequence R description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 55) chain C residue 129 type sequence R description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 56) chain C residue 130 type sequence Y description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 57) chain C residue 175 type sequence N description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 58) chain C residue 178 type sequence V description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 59) chain C residue 222 type sequence L description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 60) chain C residue 226 type sequence N description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 61) chain F residue 154 type sequence R description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 62) chain F residue 157 type sequence Q description binding site for Di-peptide GLU F 155 and TPO F 156 source : AD1 63) chain C residue 56 type sequence R description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 64) chain C residue 122 type sequence K description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 65) chain C residue 129 type sequence R description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 66) chain C residue 130 type sequence Y description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 67) chain C residue 175 type sequence N description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 68) chain C residue 178 type sequence V description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 69) chain C residue 218 type sequence L description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 70) chain F residue 154 type sequence R description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 71) chain F residue 155 type sequence E description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 72) chain F residue 158 type sequence L description binding site for Di-peptide TPO F 156 and GLN F 157 source : AD2 73) chain D residue 49 type sequence K description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 74) chain D residue 56 type sequence R description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 75) chain D residue 129 type sequence R description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 76) chain D residue 130 type sequence Y description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 77) chain D residue 174 type sequence L description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 78) chain D residue 175 type sequence N description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 79) chain D residue 178 type sequence V description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 80) chain D residue 222 type sequence L description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 81) chain D residue 226 type sequence N description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 82) chain G residue 151 type sequence R description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 83) chain G residue 154 type sequence R description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 84) chain G residue 157 type sequence Q description binding site for Di-peptide GLU G 155 and TPO G 156 source : AD3 85) chain D residue 49 type sequence K description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 86) chain D residue 56 type sequence R description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 87) chain D residue 122 type sequence K description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 88) chain D residue 129 type sequence R description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 89) chain D residue 130 type sequence Y description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 90) chain D residue 174 type sequence L description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 91) chain D residue 175 type sequence N description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 92) chain D residue 222 type sequence L description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 93) chain G residue 154 type sequence R description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 94) chain G residue 155 type sequence E description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 95) chain G residue 158 type sequence L description binding site for Di-peptide TPO G 156 and GLN G 157 source : AD4 96) chain A residue 41-51 type prosite sequence RNLLSVAYKNV description 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV source prosite : PS00796 97) chain A residue 56 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 98) chain A residue 129 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 99) chain B residue 56 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 100) chain B residue 129 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 101) chain C residue 56 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 102) chain C residue 129 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 103) chain D residue 56 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 104) chain D residue 129 type SITE sequence R description Interaction with phosphoserine on interacting protein source Swiss-Prot : SWS_FT_FI1 105) chain A residue 5 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI2 106) chain B residue 5 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI2 107) chain C residue 5 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI2 108) chain D residue 5 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI2 109) chain A residue 74 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 110) chain D residue 74 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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