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eF-site ID
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6tka-.AAA |
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PDB Code
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6tka |
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Chain
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AAA |
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click to enlarge
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Title
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Crystal structure of human O-GlcNAc transferase bound to substrate 7 and a peptide from HCF-1 pro-repeat 2 (11-26) |
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Classification
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TRANSFERASE |
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Compound
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UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
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Source
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(6TKA) |
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Sequence
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AAA: |
ACPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA
AAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM
GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD
SGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTD
YDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYV
SSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNF
RVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNG
YTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQ
ETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFIYDNRIVLNGIDLKAFLDSLPDVKIVKNMPVIPMNTIA
EAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEV
PRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWAN
ILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFS
PVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPM
VTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKL
GTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQM
WEHYAAGNKPDHMI
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Description
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Functional site
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1)
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chain |
AAA |
| residue |
624 |
| type |
ACT_SITE |
| sequence |
H
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| description |
Proton acceptor => ECO:0000305|PubMed:21240259, ECO:0000305|PubMed:26678539
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
AAA |
| residue |
570 |
| type |
MOD_RES |
| sequence |
M
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| description |
Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260
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| source |
Swiss-Prot : SWS_FT_FI3
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3)
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chain |
AAA |
| residue |
515 |
| type |
CARBOHYD |
| sequence |
E
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| description |
O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473
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| source |
Swiss-Prot : SWS_FT_FI4
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4)
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chain |
AAA |
| residue |
965 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW
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| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
AAA |
| residue |
968 |
| type |
BINDING |
| sequence |
D
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| description |
BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW
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| source |
Swiss-Prot : SWS_FT_FI2
|
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6)
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chain |
AAA |
| residue |
1022 |
| type |
BINDING |
| sequence |
K
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| description |
BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW
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| source |
Swiss-Prot : SWS_FT_FI2
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7)
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chain |
AAA |
| residue |
1027 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW
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| source |
Swiss-Prot : SWS_FT_FI2
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