eF-site ID 6t8z-.AAA PDB Code 6t8z Chain AAA click to enlarge Title NAD+-dependent fungal formate dehydrogenase from Chaetomium thermophilum: A ternary complex with the oxidised form of the cofactor NAD+ and the substrate formate both at a primary and secondary sites. Classification CYTOSOLIC PROTEIN Compound Formate dehydrogenase Source (FDH_CHATD) Sequence AAA:  TARLQMVKVLAVLYDGGEHAKQVPGLLGTTENELGLRKWL EDQGHTLVTTSDKDREGSTFDRELEDAEIIITTPFHPGYL TAERLARAKKLKLAVTAGIGSDHVDLDAANKTNGGITVAE VTGSNVVSVAEHVVMTILVLVRNFVPAHEQIEAGRWDVAE VAKDEYDLEGKVVGTVGVGRIGERVLRRLKGFDCKELLYY DYQPLSPEKEKEIGCRRVENLEEMLAQCDVVTINCPLHES TRGLFNKDLISKMKRGSWLVNTARGAIVVKEDVAEALRTG HLRGYGGDVWFPQPAPADHVLRTAKNPFGGGNAMVPHMSG TSLDAQKRYAEGVKRILDSYLSGRFDYRPEDLIVHQGKYA TRAYGQREDVKIP Description Functional site 1) chain AAA residue 94 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 2) chain AAA residue 120 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 3) chain AAA residue 175 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 4) chain AAA residue 196 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 5) chain AAA residue 231 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 6) chain AAA residue 257 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 7) chain AAA residue 283 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 8) chain AAA residue 312 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 9) chain AAA residue 259 type SITE sequence R description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 10) chain AAA residue 312 type SITE sequence H description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 11) chain AAA residue 168-196 type prosite sequence VGTVGVGRIGERVLRRLKGFDCKELLYYD description D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VGTVGvGRIGervlrrlkgfdckeLLyYD source prosite : PS00065 12) chain AAA residue 219-241 type prosite sequence MLAQCDVVTINCPLHESTRGLFN description D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. MLaqCDVVtINcPlhesTrgLfN source prosite : PS00670 13) chain AAA residue 248-264 type prosite sequence MKRGSWLVNTARGAIVV description D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKrGsWLVNtARGaIVV source prosite : PS00671

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