eF-site ID 6t8y-.AAA.BBB.CCC.DDD PDB Code 6t8y Chain AAA, BBB, CCC, DDD click to enlarge Title NAD+-dependent fungal formate dehydrogenase from Chaetomium thermophilum: A complex with the reduced form of the cofactor NADH and the substrate formate at a secondary site. Classification CYTOSOLIC PROTEIN Compound Formate dehydrogenase Source (FDH_CHATD) Sequence AAA:  ARLQMVKVLAVLYDGGEHAKQVPGLLGTTENELGLRKWLE DQGHTLVTTSDKDREGSTFDRELEDAEIIITTPFHPGYLT AERLARAKKLKLAVTAGIGSDHVDLDAANKTNGGITVAEV TGSNVVSVAEHVVMTILVLVRNFVPAHEQIEAGRWDVAEV AKDEYDLEGKVVGTVGVGRIGERVLRRLKGFDCKELLYYD YQPLSPEKEKEIGCRRVENLEEMLAQCDVVTINCPLHEST RGLFNKDLISKMKRGSWLVNTARGAIVVKEDVAEALRTGH LRGYGGDVWFPQPAPADHVLRTAKNPFGGGNAMVPHMSGT SLDAQKRYAEGVKRILDSYLSGRFDYRPEDLIVHQGKYAT RAYGQREDVKIP BBB:  YTARLQMVKVLAVLYDGGEHAKQVPGLLGTTENELGLRKW LEDQGHTLVTTSDKDREGSTFDRELEDAEIIITTPFHPGY LTAERLARAKKLKLAVTAGIGSDHVDLDAANKTNGGITVA EVTGSNVVSVAEHVVMTILVLVRNFVPAHEQIEAGRWDVA EVAKDEYDLEGKVVGTVGVGRIGERVLRRLKGFDCKELLY YDYQPLSPEKEKEIGCRRVENLEEMLAQCDVVTINCPLHE STRGLFNKDLISKMKRGSWLVNTARGAIVVKEDVAEALRT GHLRGYGGDVWFPQPAPADHVLRTAKNPFGGGNAMVPHMS GTSLDAQKRYAEGVKRILDSYLSGRFDYRPEDLIVHQGKY ATRAYGQREDVKIPG CCC:  ARLQMVKVLAVLYDGGEHAKQVPGLLGTTENELGLRKWLE DQGHTLVTTSDKDREGSTFDRELEDAEIIITTPFHPGYLT AERLARAKKLKLAVTAGIGSDHVDLDAANKTNGGITVAEV TGSNVVSVAEHVVMTILVLVRNFVPAHEQIEAGRWDVAEV AKDEYDLEGKVVGTVGVGRIGERVLRRLKGFDCKELLYYD YQPLSPEKEKEIGCRRVENLEEMLAQCDVVTINCPLHEST RGLFNKDLISKMKRGSWLVNTARGAIVVKEDVAEALRTGH LRGYGGDVWFPQPAPADHVLRTAKNPFGGGNAMVPHMSGT SLDAQKRYAEGVKRILDSYLSGRFDYRPEDLIVHQGKYAT RAYGQREDVKIPG DDD:  TARLQMVKVLAVLYDGGEHAKQVPGLLGTTENELGLRKWL EDQGHTLVTTSDKDREGSTFDRELEDAEIIITTPFHPGYL TAERLARAKKLKLAVTAGIGSDHVDLDAANKTNGGITVAE VTGSNVVSVAEHVVMTILVLVRNFVPAHEQIEAGRWDVAE VAKDEYDLEGKVVGTVGVGRIGERVLRRLKGFDCKELLYY DYQPLSPEKEKEIGCRRVENLEEMLAQCDVVTINCPLHES TRGLFNKDLISKMKRGSWLVNTARGAIVVKEDVAEALRTG HLRGYGGDVWFPQPAPADHVLRTAKNPFGGGNAMVPHMSG TSLDAQKRYAEGVKRILDSYLSGRFDYRPEDLIVHQGKYA TRAYGQREDVKIPG Description Functional site 1) chain AAA residue 94 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 2) chain BBB residue 120 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 3) chain BBB residue 175 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 4) chain BBB residue 196 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 5) chain BBB residue 231 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 6) chain BBB residue 257 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 7) chain BBB residue 283 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 8) chain BBB residue 312 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 9) chain CCC residue 94 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 10) chain CCC residue 120 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 11) chain CCC residue 175 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 12) chain AAA residue 120 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 13) chain CCC residue 196 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 14) chain CCC residue 231 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 15) chain CCC residue 257 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 16) chain CCC residue 283 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 17) chain CCC residue 312 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 18) chain DDD residue 94 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 19) chain DDD residue 120 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 20) chain DDD residue 175 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 21) chain DDD residue 196 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 22) chain DDD residue 231 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 23) chain AAA residue 175 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 24) chain DDD residue 257 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 25) chain DDD residue 283 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 26) chain DDD residue 312 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 27) chain AAA residue 196 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 28) chain AAA residue 231 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 29) chain AAA residue 257 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 30) chain AAA residue 283 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 31) chain AAA residue 312 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 32) chain BBB residue 94 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI1 33) chain AAA residue 259 type SITE sequence R description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 34) chain AAA residue 312 type SITE sequence H description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 35) chain BBB residue 259 type SITE sequence R description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 36) chain BBB residue 312 type SITE sequence H description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 37) chain CCC residue 259 type SITE sequence R description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 38) chain CCC residue 312 type SITE sequence H description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 39) chain DDD residue 259 type SITE sequence R description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 40) chain DDD residue 312 type SITE sequence H description Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03210 source Swiss-Prot : SWS_FT_FI2 41) chain AAA residue 168-196 type prosite sequence VGTVGVGRIGERVLRRLKGFDCKELLYYD description D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VGTVGvGRIGervlrrlkgfdckeLLyYD source prosite : PS00065 42) chain AAA residue 219-241 type prosite sequence MLAQCDVVTINCPLHESTRGLFN description D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. MLaqCDVVtINcPlhesTrgLfN source prosite : PS00670 43) chain AAA residue 248-264 type prosite sequence MKRGSWLVNTARGAIVV description D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKrGsWLVNtARGaIVV source prosite : PS00671

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