eF-site ID 6rqx-A PDB Code 6rqx Chain A click to enlarge Title High-resolution crystal structure of ERAP1 in complex with 10mer phosphinic peptide Classification HYDROLASE Compound Endoplasmic reticulum aminopeptidase 1 Source (6RQX) Sequence A:  PFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEIT ASQPTSTIILHSHHLQISRATLRKGAGERLSEEPLQVLEH PRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKS TYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSI KIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTY LVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDA AVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLT TYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVT MEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCF DAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACIL NMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASI VDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGSA PDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVE WIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDR ASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQG LNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTW TDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKE SNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSST EKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQIL TLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVM GTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIE ENIGWMDKNFDKIRVWLQSEKL Description Functional site 1) chain A residue 354 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095 source Swiss-Prot : SWS_FT_FI3 2) chain A residue 183 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 3) chain A residue 317 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 4) chain A residue 353 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI5 5) chain A residue 357 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI5 6) chain A residue 376 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI5 7) chain A residue 350-359 type prosite sequence TVAHELAHQW description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHELAHQW source prosite : PS00142 8) chain A residue 901 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI10 9) chain A residue 414 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|Ref.16 source Swiss-Prot : SWS_FT_FI8 10) chain A residue 760 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21478864 source Swiss-Prot : SWS_FT_FI9 11) chain A residue 438 type SITE sequence Y description Transition state stabilizer => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 12) chain A residue 70 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21478864, ECO:0000269|Ref.16 source Swiss-Prot : SWS_FT_FI7 13) chain A residue 154 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21478864, ECO:0000269|Ref.16 source Swiss-Prot : SWS_FT_FI7

Display surface Download Links