eF-site ID 6rn8-AB PDB Code 6rn8 Chain A, B click to enlarge Title RIP2 Kinase Catalytic Domain complex with 2(4[(1,3benzothiazol5yl)amino]6(2methylpropane2sulfonyl)quinazolin7yl)oxy)ethyl phosphate Classification TRANSFERASE Compound Receptor-interacting serine/threonine-protein kinase 2 Source (RIPK2_HUMAN) Sequence A:  AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQV AVKHLHPLLDSERKDVLREAEILHKARFSYILPILGICNE PEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHE IALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGL SKWRMGTIIYMPPENYESIKHDIYSYAVITWEVLSRKQPF EDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLI ESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQL K B:  AICSALPTIPYHKLADLRYLSRGAGTVSSARHADWRVQVA VKHLHIPLLDSERKDVLREAEILHKARFSYILPILGICNE PEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHE IALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGL SKWRMEGGTIIYMPPENYEPSIKHDIYSYAVITWEVLSRK QPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMI SLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAV IQLK Description Functional site 1) chain A residue 24 type sequence L description binding site for residue K9T A 401 source : AC1 2) chain A residue 25 type sequence S description binding site for residue K9T A 401 source : AC1 3) chain A residue 32 type sequence V description binding site for residue K9T A 401 source : AC1 4) chain A residue 45 type sequence A description binding site for residue K9T A 401 source : AC1 5) chain A residue 47 type sequence K description binding site for residue K9T A 401 source : AC1 6) chain A residue 66 type sequence E description binding site for residue K9T A 401 source : AC1 7) chain A residue 70 type sequence L description binding site for residue K9T A 401 source : AC1 8) chain A residue 79 type sequence L description binding site for residue K9T A 401 source : AC1 9) chain A residue 95 type sequence T description binding site for residue K9T A 401 source : AC1 10) chain A residue 96 type sequence E description binding site for residue K9T A 401 source : AC1 11) chain A residue 97 type sequence Y description binding site for residue K9T A 401 source : AC1 12) chain A residue 98 type sequence M description binding site for residue K9T A 401 source : AC1 13) chain A residue 105 type sequence E description binding site for residue K9T A 401 source : AC1 14) chain A residue 153 type sequence L description binding site for residue K9T A 401 source : AC1 15) chain A residue 163 type sequence A description binding site for residue K9T A 401 source : AC1 16) chain A residue 164 type sequence D description binding site for residue K9T A 401 source : AC1 17) chain B residue 112 type sequence E description binding site for residue CA B 401 source : AC2 18) chain B residue 24 type sequence L description binding site for residue K9T B 402 source : AC3 19) chain B residue 25 type sequence S description binding site for residue K9T B 402 source : AC3 20) chain B residue 32 type sequence V description binding site for residue K9T B 402 source : AC3 21) chain B residue 45 type sequence A description binding site for residue K9T B 402 source : AC3 22) chain B residue 47 type sequence K description binding site for residue K9T B 402 source : AC3 23) chain B residue 66 type sequence E description binding site for residue K9T B 402 source : AC3 24) chain B residue 70 type sequence L description binding site for residue K9T B 402 source : AC3 25) chain B residue 79 type sequence L description binding site for residue K9T B 402 source : AC3 26) chain B residue 95 type sequence T description binding site for residue K9T B 402 source : AC3 27) chain B residue 96 type sequence E description binding site for residue K9T B 402 source : AC3 28) chain B residue 97 type sequence Y description binding site for residue K9T B 402 source : AC3 29) chain B residue 98 type sequence M description binding site for residue K9T B 402 source : AC3 30) chain B residue 101 type sequence G description binding site for residue K9T B 402 source : AC3 31) chain B residue 105 type sequence E description binding site for residue K9T B 402 source : AC3 32) chain B residue 153 type sequence L description binding site for residue K9T B 402 source : AC3 33) chain B residue 163 type sequence A description binding site for residue K9T B 402 source : AC3 34) chain B residue 164 type sequence D description binding site for residue K9T B 402 source : AC3 35) chain A residue 146 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:9705938 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 146 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:9705938 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 209 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18079694 source Swiss-Prot : SWS_FT_FI10 38) chain B residue 209 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18079694 source Swiss-Prot : SWS_FT_FI10 39) chain A residue 142-154 type prosite sequence LLHHDLKTQNILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHhDLKtqNILL source prosite : PS00108 40) chain B residue 24 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 24 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 47 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 43) chain B residue 47 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 44) chain A residue 149 type MOD_RES sequence T description (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 source Swiss-Prot : SWS_FT_FI4 45) chain A residue 189 type MOD_RES sequence T description (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 source Swiss-Prot : SWS_FT_FI4 46) chain B residue 149 type MOD_RES sequence T description (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 source Swiss-Prot : SWS_FT_FI4 47) chain B residue 189 type MOD_RES sequence T description (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 source Swiss-Prot : SWS_FT_FI4 48) chain A residue 168 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 49) chain B residue 168 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5

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