eF-site ID 6rn8-A PDB Code 6rn8 Chain A click to enlarge Title RIP2 Kinase Catalytic Domain complex with 2(4[(1,3benzothiazol5yl)amino]6(2methylpropane2sulfonyl)quinazolin7yl)oxy)ethyl phosphate Classification TRANSFERASE Compound Receptor-interacting serine/threonine-protein kinase 2 Source (RIPK2_HUMAN) Sequence A:  AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQV AVKHLHPLLDSERKDVLREAEILHKARFSYILPILGICNE PEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHE IALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGL SKWRMGTIIYMPPENYESIKHDIYSYAVITWEVLSRKQPF EDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLI ESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQL K Description Functional site 1) chain A residue 24 type sequence L description binding site for residue K9T A 401 source : AC1 2) chain A residue 25 type sequence S description binding site for residue K9T A 401 source : AC1 3) chain A residue 32 type sequence V description binding site for residue K9T A 401 source : AC1 4) chain A residue 45 type sequence A description binding site for residue K9T A 401 source : AC1 5) chain A residue 47 type sequence K description binding site for residue K9T A 401 source : AC1 6) chain A residue 66 type sequence E description binding site for residue K9T A 401 source : AC1 7) chain A residue 70 type sequence L description binding site for residue K9T A 401 source : AC1 8) chain A residue 79 type sequence L description binding site for residue K9T A 401 source : AC1 9) chain A residue 95 type sequence T description binding site for residue K9T A 401 source : AC1 10) chain A residue 96 type sequence E description binding site for residue K9T A 401 source : AC1 11) chain A residue 97 type sequence Y description binding site for residue K9T A 401 source : AC1 12) chain A residue 98 type sequence M description binding site for residue K9T A 401 source : AC1 13) chain A residue 105 type sequence E description binding site for residue K9T A 401 source : AC1 14) chain A residue 153 type sequence L description binding site for residue K9T A 401 source : AC1 15) chain A residue 163 type sequence A description binding site for residue K9T A 401 source : AC1 16) chain A residue 164 type sequence D description binding site for residue K9T A 401 source : AC1 17) chain A residue 146 type ACT_SITE sequence D description Proton acceptor => ECO:0000269|PubMed:9705938 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 24 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 47 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 20) chain A residue 149 type MOD_RES sequence T description (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 189 type MOD_RES sequence T description (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 168 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 23) chain A residue 142-154 type prosite sequence LLHHDLKTQNILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHhDLKtqNILL source prosite : PS00108 24) chain A residue 209 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18079694 source Swiss-Prot : SWS_FT_FI10

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