eF-site ID 6rfk-EIS PDB Code 6rfk Chain E, I, S click to enlarge Title Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant) Classification HYDROLASE Compound Coagulation factor IX Source (6RFK) Sequence E:  MDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKS CEPAVPFPCGRVSVSQTSKLTR I:  EGXX S:  VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAA HCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYN AAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL KFGSGYVSGWGRVFHQGQSALVLQYLRVPLVDRATCLRST KFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT Description Functional site 1) chain E residue 92 type sequence N description binding site for residue B3P E 201 source : AC1 2) chain E residue 94 type sequence R description binding site for residue B3P E 201 source : AC1 3) chain E residue 95 type sequence C description binding site for residue B3P E 201 source : AC1 4) chain E residue 96 type sequence E description binding site for residue B3P E 201 source : AC1 5) chain E residue 122 type sequence K description binding site for residue B3P E 201 source : AC1 6) chain E residue 123 type sequence S description binding site for residue B3P E 201 source : AC1 7) chain S residue 204 type sequence E description binding site for residue B3P E 201 source : AC1 8) chain S residue 70 type sequence E description binding site for residue CA S 301 source : AC2 9) chain S residue 72 type sequence N description binding site for residue CA S 301 source : AC2 10) chain S residue 75 type sequence E description binding site for residue CA S 301 source : AC2 11) chain S residue 77 type sequence E description binding site for residue CA S 301 source : AC2 12) chain S residue 80 type sequence E description binding site for residue CA S 301 source : AC2 13) chain E residue 88 type sequence C description binding site for residue GOL S 302 source : AC3 14) chain E residue 99 type sequence C description binding site for residue GOL S 302 source : AC3 15) chain S residue 127 type sequence E description binding site for residue GOL S 302 source : AC3 16) chain S residue 128 type sequence Y description binding site for residue GOL S 302 source : AC3 17) chain S residue 129 type sequence T description binding site for residue GOL S 302 source : AC3 18) chain S residue 170 type sequence R description binding site for residue GOL S 302 source : AC3 19) chain S residue 185 type sequence H description binding site for residue GOL S 303 source : AC4 20) chain S residue 202 type sequence E description binding site for residue GOL S 303 source : AC4 21) chain S residue 203 type sequence V description binding site for residue GOL S 303 source : AC4 22) chain S residue 204 type sequence E description binding site for residue GOL S 303 source : AC4 23) chain S residue 35 type sequence G description binding site for residue GOL S 304 source : AC5 24) chain S residue 37 type sequence K description binding site for residue GOL S 304 source : AC5 25) chain S residue 38 type sequence V description binding site for residue GOL S 304 source : AC5 26) chain S residue 41 type sequence F description binding site for residue GOL S 304 source : AC5 27) chain S residue 58 type sequence C description binding site for residue GOL S 304 source : AC5 28) chain S residue 62 type sequence V description binding site for residue GOL S 304 source : AC5 29) chain S residue 63 type sequence K description binding site for residue GOL S 304 source : AC5 30) chain S residue 97 type sequence N description binding site for residue GOL S 305 source : AC6 31) chain S residue 99 type sequence Y description binding site for residue GOL S 305 source : AC6 32) chain S residue 174 type sequence F description binding site for residue GOL S 305 source : AC6 33) chain S residue 175 type sequence T description binding site for residue GOL S 305 source : AC6 34) chain S residue 177 type sequence Y description binding site for residue GOL S 305 source : AC6 35) chain S residue 215 type sequence W description binding site for residue GOL S 305 source : AC6 36) chain S residue 171 type sequence S description binding site for residue GOL S 306 source : AC7 37) chain S residue 172 type sequence T description binding site for residue GOL S 306 source : AC7 38) chain S residue 216 type sequence G description binding site for residue GOL S 306 source : AC7 39) chain S residue 217 type sequence E description binding site for residue GOL S 306 source : AC7 40) chain S residue 224 type sequence K description binding site for residue GOL S 306 source : AC7 41) chain S residue 225 type sequence Y description binding site for residue GOL S 306 source : AC7 42) chain S residue 21 type sequence D description binding site for residue GOL S 307 source : AC8 43) chain S residue 153 type sequence L description binding site for residue GOL S 307 source : AC8 44) chain S residue 154 type sequence V description binding site for residue GOL S 307 source : AC8 45) chain S residue 70 type sequence E description binding site for residue GOL S 308 source : AC9 46) chain S residue 72 type sequence N description binding site for residue GOL S 308 source : AC9 47) chain S residue 73 type sequence I description binding site for residue GOL S 308 source : AC9 48) chain S residue 75 type sequence E description binding site for residue GOL S 308 source : AC9 49) chain S residue 80 type sequence E description binding site for residue GOL S 308 source : AC9 50) chain S residue 91 type sequence H description binding site for residue GOL S 309 source : AD1 51) chain S residue 93 type sequence N description binding site for residue GOL S 309 source : AD1 52) chain S residue 101 type sequence H description binding site for residue GOL S 309 source : AD1 53) chain S residue 233 type sequence R description binding site for residue GOL S 309 source : AD1 54) chain S residue 126 type sequence K description binding site for residue GOL S 310 source : AD2 55) chain S residue 129 type sequence T description binding site for residue GOL S 310 source : AD2 56) chain S residue 230 type sequence K description binding site for residue GOL S 310 source : AD2 57) chain S residue 232 type sequence S description binding site for residue GOL S 310 source : AD2 58) chain S residue 233 type sequence R description binding site for residue GOL S 310 source : AD2 59) chain S residue 132 type sequence K description binding site for residue GOL S 311 source : AD3 60) chain S residue 162 type sequence L description binding site for residue GOL S 311 source : AD3 61) chain S residue 164 type sequence D description binding site for residue GOL S 311 source : AD3 62) chain S residue 164 type sequence D description binding site for residue GOL S 311 source : AD3 63) chain I residue 1 type sequence E description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 64) chain I residue 2 type sequence G description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 65) chain S residue 57 type sequence H description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 66) chain S residue 189 type sequence D description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 67) chain S residue 190 type sequence S description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 68) chain S residue 191 type sequence C description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 69) chain S residue 192 type sequence Q description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 70) chain S residue 193 type sequence G description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 71) chain S residue 195 type sequence S description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 72) chain S residue 214 type sequence S description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 73) chain S residue 215 type sequence W description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 74) chain S residue 216 type sequence G description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 75) chain S residue 219 type sequence E description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 76) chain S residue 220 type sequence C description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 77) chain S residue 226 type sequence G description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 78) chain S residue 70 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3 79) chain S residue 72 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3 80) chain S residue 75 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3 81) chain S residue 77 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3 82) chain S residue 80 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI4 83) chain S residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:659613 source Swiss-Prot : SWS_FT_FI1 84) chain S residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:659613 source Swiss-Prot : SWS_FT_FI1 85) chain S residue 53-58 type prosite sequence VTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC source prosite : PS00134 86) chain S residue 189-200 type prosite sequence DSCQGDSGGPHV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV source prosite : PS00135 87) chain E residue 109-124 type prosite sequence CSCTEGYRLAENQKSC description EGF_2 EGF-like domain signature 2. CsCteGYrlaenqksC source prosite : PS01186 88) chain S residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000269|PubMed:659613 source Swiss-Prot : SWS_FT_FI2

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