eF-site ID 6rfk-S PDB Code 6rfk Chain S click to enlarge Title Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant) Classification HYDROLASE Compound Coagulation factor IX Source (6RFK) Sequence S:  VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAA HCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYN AAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL KFGSGYVSGWGRVFHQGQSALVLQYLRVPLVDRATCLRST KFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT Description Functional site 1) chain S residue 204 type sequence E description binding site for residue B3P E 201 source : AC1 2) chain S residue 70 type sequence E description binding site for residue CA S 301 source : AC2 3) chain S residue 72 type sequence N description binding site for residue CA S 301 source : AC2 4) chain S residue 75 type sequence E description binding site for residue CA S 301 source : AC2 5) chain S residue 77 type sequence E description binding site for residue CA S 301 source : AC2 6) chain S residue 80 type sequence E description binding site for residue CA S 301 source : AC2 7) chain S residue 127 type sequence E description binding site for residue GOL S 302 source : AC3 8) chain S residue 128 type sequence Y description binding site for residue GOL S 302 source : AC3 9) chain S residue 129 type sequence T description binding site for residue GOL S 302 source : AC3 10) chain S residue 170 type sequence R description binding site for residue GOL S 302 source : AC3 11) chain S residue 185 type sequence H description binding site for residue GOL S 303 source : AC4 12) chain S residue 202 type sequence E description binding site for residue GOL S 303 source : AC4 13) chain S residue 203 type sequence V description binding site for residue GOL S 303 source : AC4 14) chain S residue 204 type sequence E description binding site for residue GOL S 303 source : AC4 15) chain S residue 35 type sequence G description binding site for residue GOL S 304 source : AC5 16) chain S residue 37 type sequence K description binding site for residue GOL S 304 source : AC5 17) chain S residue 38 type sequence V description binding site for residue GOL S 304 source : AC5 18) chain S residue 41 type sequence F description binding site for residue GOL S 304 source : AC5 19) chain S residue 58 type sequence C description binding site for residue GOL S 304 source : AC5 20) chain S residue 62 type sequence V description binding site for residue GOL S 304 source : AC5 21) chain S residue 63 type sequence K description binding site for residue GOL S 304 source : AC5 22) chain S residue 97 type sequence N description binding site for residue GOL S 305 source : AC6 23) chain S residue 99 type sequence Y description binding site for residue GOL S 305 source : AC6 24) chain S residue 174 type sequence F description binding site for residue GOL S 305 source : AC6 25) chain S residue 175 type sequence T description binding site for residue GOL S 305 source : AC6 26) chain S residue 177 type sequence Y description binding site for residue GOL S 305 source : AC6 27) chain S residue 215 type sequence W description binding site for residue GOL S 305 source : AC6 28) chain S residue 171 type sequence S description binding site for residue GOL S 306 source : AC7 29) chain S residue 172 type sequence T description binding site for residue GOL S 306 source : AC7 30) chain S residue 216 type sequence G description binding site for residue GOL S 306 source : AC7 31) chain S residue 217 type sequence E description binding site for residue GOL S 306 source : AC7 32) chain S residue 224 type sequence K description binding site for residue GOL S 306 source : AC7 33) chain S residue 225 type sequence Y description binding site for residue GOL S 306 source : AC7 34) chain S residue 21 type sequence D description binding site for residue GOL S 307 source : AC8 35) chain S residue 153 type sequence L description binding site for residue GOL S 307 source : AC8 36) chain S residue 154 type sequence V description binding site for residue GOL S 307 source : AC8 37) chain S residue 70 type sequence E description binding site for residue GOL S 308 source : AC9 38) chain S residue 72 type sequence N description binding site for residue GOL S 308 source : AC9 39) chain S residue 73 type sequence I description binding site for residue GOL S 308 source : AC9 40) chain S residue 75 type sequence E description binding site for residue GOL S 308 source : AC9 41) chain S residue 80 type sequence E description binding site for residue GOL S 308 source : AC9 42) chain S residue 91 type sequence H description binding site for residue GOL S 309 source : AD1 43) chain S residue 93 type sequence N description binding site for residue GOL S 309 source : AD1 44) chain S residue 101 type sequence H description binding site for residue GOL S 309 source : AD1 45) chain S residue 233 type sequence R description binding site for residue GOL S 309 source : AD1 46) chain S residue 126 type sequence K description binding site for residue GOL S 310 source : AD2 47) chain S residue 129 type sequence T description binding site for residue GOL S 310 source : AD2 48) chain S residue 230 type sequence K description binding site for residue GOL S 310 source : AD2 49) chain S residue 232 type sequence S description binding site for residue GOL S 310 source : AD2 50) chain S residue 233 type sequence R description binding site for residue GOL S 310 source : AD2 51) chain S residue 132 type sequence K description binding site for residue GOL S 311 source : AD3 52) chain S residue 162 type sequence L description binding site for residue GOL S 311 source : AD3 53) chain S residue 164 type sequence D description binding site for residue GOL S 311 source : AD3 54) chain S residue 164 type sequence D description binding site for residue GOL S 311 source : AD3 55) chain S residue 57 type sequence H description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 56) chain S residue 189 type sequence D description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 57) chain S residue 190 type sequence S description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 58) chain S residue 191 type sequence C description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 59) chain S residue 192 type sequence Q description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 60) chain S residue 193 type sequence G description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 61) chain S residue 195 type sequence S description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 62) chain S residue 214 type sequence S description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 63) chain S residue 215 type sequence W description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 64) chain S residue 216 type sequence G description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 65) chain S residue 219 type sequence E description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 66) chain S residue 220 type sequence C description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 67) chain S residue 226 type sequence G description binding site for residues AR7 I 3 and 0QE I 4 source : AD4 68) chain S residue 80 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI4 69) chain S residue 53-58 type prosite sequence VTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC source prosite : PS00134 70) chain S residue 189-200 type prosite sequence DSCQGDSGGPHV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV source prosite : PS00135 71) chain S residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:659613 source Swiss-Prot : SWS_FT_FI1 72) chain S residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:659613 source Swiss-Prot : SWS_FT_FI1 73) chain S residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000269|PubMed:659613 source Swiss-Prot : SWS_FT_FI2 74) chain S residue 75 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3 75) chain S residue 77 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3 76) chain S residue 70 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3 77) chain S residue 72 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 source Swiss-Prot : SWS_FT_FI3

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