eF-site ID 6r91-A
PDB Code 6r91
Chain A

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Title Cryo-EM structure of NCP_THF2(-3)-UV-DDB
Classification DNA BINDING PROTEIN
Compound Histone H3.1
Source (DDB2_HUMAN)
Sequence A:  VKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREI
AQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHA
KRVTIMPKDIQLARRIRGERA
Description (1)  Histone H3.1, Histone H4, Histone H2A type 1-B/E, Histone H2B type 1-J, DNA damage-binding protein 1,DNA damage-binding protein 1, DNA damage-binding protein 2/DNA Complex


Functional site

1) chain A
residue 38
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563
source Swiss-Prot : SWS_FT_FI18

2) chain A
residue 67-75
type prosite
sequence PFQRLVREI
description HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
source prosite : PS00959

3) chain A
residue 80
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711
source Swiss-Prot : SWS_FT_FI21

4) chain A
residue 81
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000269|PubMed:20850016
source Swiss-Prot : SWS_FT_FI22

5) chain A
residue 87
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P84243
source Swiss-Prot : SWS_FT_FI23

6) chain A
residue 108
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3
source Swiss-Prot : SWS_FT_FI24

7) chain A
residue 116
type MOD_RES
sequence K
description N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297
source Swiss-Prot : SWS_FT_FI25

8) chain A
residue 123
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229
source Swiss-Prot : SWS_FT_FI26


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