eF-site ID 6r8w-A PDB Code 6r8w Chain A click to enlarge Title Human Cyclophilin D in complex with 2-(exo-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-N-((1R,9R,10S)-10-hydroxy-12-oxa-8-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ylmethyl)-acetamide Classification ISOMERASE Compound Peptidyl-prolyl cis-trans isomerase F, mitochondrial Source (PPIF_HUMAN) Sequence A:  GNPLVYLDVDANGKPLGRVVLELKADVVPKTAENFRALCT GEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGS RFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDW LDGKHVVFGHVIEGMDVVKKIESFGSKSGRTSKKIVITDC GQLS Description Functional site 1) chain A residue 101 type sequence S description binding site for residue O4B A 301 source : AC1 2) chain A residue 101 type sequence S description binding site for residue O4B A 301 source : AC1 3) chain A residue 102 type sequence F description binding site for residue O4B A 301 source : AC1 4) chain A residue 102 type sequence F description binding site for residue O4B A 301 source : AC1 5) chain A residue 190 type sequence K description binding site for residue O4B A 301 source : AC1 6) chain A residue 190 type sequence K description binding site for residue O4B A 301 source : AC1 7) chain A residue 88 type sequence F description binding site for residue P6G A 302 source : AC2 8) chain A residue 120 type sequence I description binding site for residue P6G A 302 source : AC2 9) chain A residue 121 type sequence Y description binding site for residue P6G A 302 source : AC2 10) chain A residue 135 type sequence V description binding site for residue P6G A 302 source : AC2 11) chain A residue 137 type sequence P description binding site for residue P6G A 302 source : AC2 12) chain A residue 173 type sequence H description binding site for residue P6G A 302 source : AC2 13) chain A residue 97 type sequence R description binding site for residue JVH A 303 source : AC3 14) chain A residue 97 type sequence R description binding site for residue JVH A 303 source : AC3 15) chain A residue 102 type sequence F description binding site for residue JVH A 303 source : AC3 16) chain A residue 105 type sequence Q description binding site for residue JVH A 303 source : AC3 17) chain A residue 114 type sequence G description binding site for residue JVH A 303 source : AC3 18) chain A residue 115 type sequence T description binding site for residue JVH A 303 source : AC3 19) chain A residue 115 type sequence T description binding site for residue JVH A 303 source : AC3 20) chain A residue 116 type sequence G description binding site for residue JVH A 303 source : AC3 21) chain A residue 123 type sequence S description binding site for residue JVH A 303 source : AC3 22) chain A residue 124 type sequence R description binding site for residue JVH A 303 source : AC3 23) chain A residue 143 type sequence A description binding site for residue JVH A 303 source : AC3 24) chain A residue 144 type sequence N description binding site for residue JVH A 303 source : AC3 25) chain A residue 149 type sequence T description binding site for residue JVH A 303 source : AC3 26) chain A residue 151 type sequence G description binding site for residue JVH A 303 source : AC3 27) chain A residue 153 type sequence Q description binding site for residue JVH A 303 source : AC3 28) chain A residue 155 type sequence F description binding site for residue JVH A 303 source : AC3 29) chain A residue 168 type sequence H description binding site for residue JVH A 303 source : AC3 30) chain A residue 90-107 type prosite sequence YKGSTFHRVIPSFMCQAG description CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIpsFMcQAG source prosite : PS00170 31) chain A residue 67 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99KR7 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 86 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q99KR7 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 175 type MOD_RES sequence I description N6-succinyllysine => ECO:0000250|UniProtKB:Q99KR7 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 190 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q99KR7 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 167 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q99KR7 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 203 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:Q99KR7 source Swiss-Prot : SWS_FT_FI4

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