eF-site ID 6r5a-AB PDB Code 6r5a Chain A, B click to enlarge Title Crystal structure of PPEP-1(W103F) Classification HYDROLASE Compound Pro-Pro endopeptidase Source (PPEP1_PEPD6) Sequence A:  TTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKY LNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPKGFEGTGK TWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAI DHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPEEFFA ESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK B:  TTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKY LNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPKGFEGTGK TWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAI DHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPEEFFA ESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK Description Functional site 1) chain A residue 142 type sequence H description binding site for residue ZN A 301 source : AC1 2) chain A residue 146 type sequence H description binding site for residue ZN A 301 source : AC1 3) chain A residue 185 type sequence E description binding site for residue ZN A 301 source : AC1 4) chain A residue 115 type sequence G description binding site for residue TRS A 302 source : AC2 5) chain A residue 142 type sequence H description binding site for residue TRS A 302 source : AC2 6) chain A residue 143 type sequence E description binding site for residue TRS A 302 source : AC2 7) chain A residue 146 type sequence H description binding site for residue TRS A 302 source : AC2 8) chain A residue 178 type sequence Y description binding site for residue TRS A 302 source : AC2 9) chain A residue 185 type sequence E description binding site for residue TRS A 302 source : AC2 10) chain B residue 142 type sequence H description binding site for residue ZN B 301 source : AC3 11) chain B residue 146 type sequence H description binding site for residue ZN B 301 source : AC3 12) chain B residue 185 type sequence E description binding site for residue ZN B 301 source : AC3 13) chain B residue 115 type sequence G description binding site for residue TRS B 302 source : AC4 14) chain B residue 142 type sequence H description binding site for residue TRS B 302 source : AC4 15) chain B residue 143 type sequence E description binding site for residue TRS B 302 source : AC4 16) chain B residue 146 type sequence H description binding site for residue TRS B 302 source : AC4 17) chain B residue 178 type sequence Y description binding site for residue TRS B 302 source : AC4 18) chain B residue 185 type sequence E description binding site for residue TRS B 302 source : AC4 19) chain A residue 143 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 143 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 142 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 146 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 185 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 142 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 146 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 185 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 178 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 178 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 135 type SITE sequence D description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4 30) chain A residue 142 type SITE sequence H description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4 31) chain B residue 135 type SITE sequence D description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4 32) chain B residue 142 type SITE sequence H description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 178 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI5 34) chain B residue 178 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI5

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