eF-site ID 6r5a-A
PDB Code 6r5a
Chain A

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Title Crystal structure of PPEP-1(W103F)
Classification HYDROLASE
Compound Pro-Pro endopeptidase
Source (PPEP1_PEPD6)
Sequence A:  TTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKY
LNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPKGFEGTGK
TWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAI
DHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPEEFFA
ESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
Description


Functional site

1) chain A
residue 142
type
sequence H
description binding site for residue ZN A 301
source : AC1

2) chain A
residue 146
type
sequence H
description binding site for residue ZN A 301
source : AC1

3) chain A
residue 185
type
sequence E
description binding site for residue ZN A 301
source : AC1

4) chain A
residue 115
type
sequence G
description binding site for residue TRS A 302
source : AC2

5) chain A
residue 142
type
sequence H
description binding site for residue TRS A 302
source : AC2

6) chain A
residue 143
type
sequence E
description binding site for residue TRS A 302
source : AC2

7) chain A
residue 146
type
sequence H
description binding site for residue TRS A 302
source : AC2

8) chain A
residue 178
type
sequence Y
description binding site for residue TRS A 302
source : AC2

9) chain A
residue 185
type
sequence E
description binding site for residue TRS A 302
source : AC2

10) chain A
residue 143
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 142
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 146
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 185
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 178
type BINDING
sequence Y
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339
source Swiss-Prot : SWS_FT_FI3

15) chain A
residue 135
type SITE
sequence D
description Interacts with substrate peptide => ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI4

16) chain A
residue 142
type SITE
sequence H
description Interacts with substrate peptide => ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI4

17) chain A
residue 178
type SITE
sequence Y
description Transition state stabilizer => ECO:0000305|PubMed:26211609
source Swiss-Prot : SWS_FT_FI5


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