eF-site ID 6r56-B PDB Code 6r56 Chain B click to enlarge Title Crystal structure of PPEP-1(K101E/E184K) Classification HYDROLASE Compound Pro-Pro endopeptidase Source (PPEP1_PEPD6) Sequence B:  TTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKY LNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPEGWEGTGK TWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAI DHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPKEFFA ESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK Description Functional site 1) chain B residue 142 type sequence H description binding site for residue ZN B 300 source : AC3 2) chain B residue 146 type sequence H description binding site for residue ZN B 300 source : AC3 3) chain B residue 185 type sequence E description binding site for residue ZN B 300 source : AC3 4) chain B residue 115 type sequence G description binding site for residue TRS B 301 source : AC4 5) chain B residue 142 type sequence H description binding site for residue TRS B 301 source : AC4 6) chain B residue 143 type sequence E description binding site for residue TRS B 301 source : AC4 7) chain B residue 146 type sequence H description binding site for residue TRS B 301 source : AC4 8) chain B residue 178 type sequence Y description binding site for residue TRS B 301 source : AC4 9) chain B residue 185 type sequence E description binding site for residue TRS B 301 source : AC4 10) chain B residue 178 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI5 11) chain B residue 143 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 142 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 146 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 185 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 178 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 135 type SITE sequence D description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 142 type SITE sequence H description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4

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