eF-site ID 6r56-AB
PDB Code 6r56
Chain A, B

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Title Crystal structure of PPEP-1(K101E/E184K)
Classification HYDROLASE
Compound Pro-Pro endopeptidase
Source (PPEP1_PEPD6)
Sequence A:  HMDSTTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANI
DGKYLNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPEGWE
GTGKTWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHET
AHAIDHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPK
EFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
B:  TTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKY
LNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPEGWEGTGK
TWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAI
DHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPKEFFA
ESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
Description


Functional site

1) chain A
residue 142
type
sequence H
description binding site for residue ZN A 300
source : AC1

2) chain A
residue 146
type
sequence H
description binding site for residue ZN A 300
source : AC1

3) chain A
residue 185
type
sequence E
description binding site for residue ZN A 300
source : AC1

4) chain A
residue 115
type
sequence G
description binding site for residue TRS A 301
source : AC2

5) chain A
residue 142
type
sequence H
description binding site for residue TRS A 301
source : AC2

6) chain A
residue 143
type
sequence E
description binding site for residue TRS A 301
source : AC2

7) chain A
residue 146
type
sequence H
description binding site for residue TRS A 301
source : AC2

8) chain A
residue 178
type
sequence Y
description binding site for residue TRS A 301
source : AC2

9) chain A
residue 185
type
sequence E
description binding site for residue TRS A 301
source : AC2

10) chain B
residue 142
type
sequence H
description binding site for residue ZN B 300
source : AC3

11) chain B
residue 146
type
sequence H
description binding site for residue ZN B 300
source : AC3

12) chain B
residue 185
type
sequence E
description binding site for residue ZN B 300
source : AC3

13) chain B
residue 115
type
sequence G
description binding site for residue TRS B 301
source : AC4

14) chain B
residue 142
type
sequence H
description binding site for residue TRS B 301
source : AC4

15) chain B
residue 143
type
sequence E
description binding site for residue TRS B 301
source : AC4

16) chain B
residue 146
type
sequence H
description binding site for residue TRS B 301
source : AC4

17) chain B
residue 178
type
sequence Y
description binding site for residue TRS B 301
source : AC4

18) chain B
residue 185
type
sequence E
description binding site for residue TRS B 301
source : AC4

19) chain A
residue 178
type SITE
sequence Y
description Transition state stabilizer => ECO:0000305|PubMed:26211609
source Swiss-Prot : SWS_FT_FI5

20) chain B
residue 178
type SITE
sequence Y
description Transition state stabilizer => ECO:0000305|PubMed:26211609
source Swiss-Prot : SWS_FT_FI5

21) chain A
residue 143
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609
source Swiss-Prot : SWS_FT_FI1

22) chain B
residue 143
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 142
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 146
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 185
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

26) chain B
residue 142
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

27) chain B
residue 146
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

28) chain B
residue 185
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI2

29) chain A
residue 178
type BINDING
sequence Y
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339
source Swiss-Prot : SWS_FT_FI3

30) chain B
residue 178
type BINDING
sequence Y
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339
source Swiss-Prot : SWS_FT_FI3

31) chain A
residue 135
type SITE
sequence D
description Interacts with substrate peptide => ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI4

32) chain A
residue 142
type SITE
sequence H
description Interacts with substrate peptide => ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI4

33) chain B
residue 135
type SITE
sequence D
description Interacts with substrate peptide => ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI4

34) chain B
residue 142
type SITE
sequence H
description Interacts with substrate peptide => ECO:0000269|PubMed:26211609
source Swiss-Prot : SWS_FT_FI4


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