eF-site ID 6r56-A PDB Code 6r56 Chain A click to enlarge Title Crystal structure of PPEP-1(K101E/E184K) Classification HYDROLASE Compound Pro-Pro endopeptidase Source (PPEP1_PEPD6) Sequence A:  HMDSTTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANI DGKYLNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPEGWE GTGKTWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHET AHAIDHIVLNDISKSAQFKQIFAKEGRSLGNVNYLGVYPK EFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK Description Functional site 1) chain A residue 142 type sequence H description binding site for residue ZN A 300 source : AC1 2) chain A residue 146 type sequence H description binding site for residue ZN A 300 source : AC1 3) chain A residue 185 type sequence E description binding site for residue ZN A 300 source : AC1 4) chain A residue 115 type sequence G description binding site for residue TRS A 301 source : AC2 5) chain A residue 142 type sequence H description binding site for residue TRS A 301 source : AC2 6) chain A residue 143 type sequence E description binding site for residue TRS A 301 source : AC2 7) chain A residue 146 type sequence H description binding site for residue TRS A 301 source : AC2 8) chain A residue 178 type sequence Y description binding site for residue TRS A 301 source : AC2 9) chain A residue 185 type sequence E description binding site for residue TRS A 301 source : AC2 10) chain A residue 178 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI5 11) chain A residue 143 type ACT_SITE sequence E description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 142 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 146 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 185 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 178 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 135 type SITE sequence D description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4 17) chain A residue 142 type SITE sequence H description Interacts with substrate peptide => ECO:0000269|PubMed:26211609 source Swiss-Prot : SWS_FT_FI4

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