eF-site ID 6r2w-HLT
PDB Code 6r2w
Chain H, L, T

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Title Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor
Classification HYDROLASE
Compound Coagulation factor VII
Source (TF_HUMAN)
Sequence H:  IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAA
HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS
TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT
LAFVRFSLVSGWGQLLDRGATALELMVLNVPRVMTQDCEA
SYPGKITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWY
LTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRP
GVLLRAPFP
L:  ANAFLXXLRPGSLXRXCKXXQCSFXXARXIFKDAXRTKLF
WISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRN
CETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEK
T:  SGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQIST
KSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPA
GNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVG
TKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKS
SSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNR
KSTDSPVECM
Description


Functional site

1) chain T
residue 124
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

2) chain T
residue 137
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

3) chain H
residue 207
type CARBOHYD
sequence A
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

4) chain L
residue 61-72
type prosite
sequence CKDQLQSYICFC
description ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDqlqsYiCfC
source prosite : PS00010

5) chain L
residue 16-41
type prosite
sequence XCKXXQCSFXXARXIFKDAXRTKLFW
description GLA_1 Vitamin K-dependent carboxylation domain. EckEEqCsfeearEifkdaertkl.FW
source prosite : PS00011

6) chain L
residue 70-81
type prosite
sequence CFCLPAFEGRNC
description EGF_1 EGF-like domain signature 1. CfClpAfeGRnC
source prosite : PS00022

7) chain L
residue 112-127
type prosite
sequence CRCHEGYSLLADGVSC
description EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC
source prosite : PS01186

8) chain L
residue 46-70
type prosite
sequence DGDQCASSPCQNGGSCKDQLQSYIC
description EGF_CA Calcium-binding EGF-like domain signature. DgDQCassp..........Cqnggs..CkDqlqsYiC
source prosite : PS01187

9) chain H
residue 52-57
type prosite
sequence VSAAHC
description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
source prosite : PS00134

10) chain H
residue 196-207
type prosite
sequence DSCKGDSGGPHA
description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA
source prosite : PS00135

11) chain T
residue 45-62
type prosite
sequence WKSKCFYTTDTECDLTDE
description TISSUE_FACTOR Tissue factor signature. WKsKCfyTtDTECDLTDE
source prosite : PS00621

12) chain H
residue 201
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

13) chain L
residue 7
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

14) chain L
residue 14
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

15) chain L
residue 16
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

16) chain L
residue 20
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

17) chain L
residue 25
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

18) chain L
residue 26
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

19) chain L
residue 29
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

20) chain L
residue 35
type BINDING
sequence X
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

21) chain H
residue 185
type CARBOHYD
sequence M
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725
source Swiss-Prot : SWS_FT_FI3

22) chain L
residue 63
type MOD_RES
sequence D
description (3R)-3-hydroxyaspartate => ECO:0000269|PubMed:3264725
source Swiss-Prot : SWS_FT_FI4

23) chain L
residue 60
type CARBOHYD
sequence S
description O-linked (Fuc) serine => ECO:0000269|PubMed:1904059, ECO:0000269|PubMed:9023546
source Swiss-Prot : SWS_FT_FI6

24) chain L
residue 52
type CARBOHYD
sequence S
description O-linked (Xyl...) serine; alternate => ECO:0000269|PubMed:1904059, ECO:0000269|PubMed:2129367, ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:2511201
source Swiss-Prot : SWS_FT_FI5


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