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eF-site ID
|
6r2w-H |
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PDB Code
|
6r2w |
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Chain
|
H |
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click to enlarge
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Title
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Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor |
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Classification
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HYDROLASE |
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Compound
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Coagulation factor VII |
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Source
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(TF_HUMAN) |
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Sequence
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H: |
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAA
HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS
TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT
LAFVRFSLVSGWGQLLDRGATALELMVLNVPRVMTQDCEA
SYPGKITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWY
LTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRP
GVLLRAPFP
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Description
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Functional site
|
|
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1)
|
chain |
H |
| residue |
52-57 |
| type |
prosite |
| sequence |
VSAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
|
| source |
prosite : PS00134
|
|
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2)
|
chain |
H |
| residue |
196-207 |
| type |
prosite |
| sequence |
DSCKGDSGGPHA
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA
|
| source |
prosite : PS00135
|
|
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3)
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chain |
H |
| residue |
207 |
| type |
CARBOHYD |
| sequence |
A
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
H |
| residue |
201 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
H |
| residue |
185 |
| type |
CARBOHYD |
| sequence |
M
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725
|
| source |
Swiss-Prot : SWS_FT_FI3
|
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