eF-site ID 6qy9-A PDB Code 6qy9 Chain A click to enlarge Title Human CSNK2A2 bound to a Pyrrolo[2,3-d]pyrimidinyl inhibitor Classification TRANSFERASE Compound Casein kinase II subunit alpha' Source (CSK22_HUMAN) Sequence A:  GSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKL GRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKIL ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMID HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFI HSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY PVVKEQSQP Description Functional site 1) chain A residue 44 type sequence R description binding site for residue JL2 A 401 source : AC1 2) chain A residue 48 type sequence R description binding site for residue JL2 A 401 source : AC1 3) chain A residue 49 type sequence G description binding site for residue JL2 A 401 source : AC1 4) chain A residue 52 type sequence S description binding site for residue JL2 A 401 source : AC1 5) chain A residue 53 type sequence E description binding site for residue JL2 A 401 source : AC1 6) chain A residue 54 type sequence V description binding site for residue JL2 A 401 source : AC1 7) chain A residue 67 type sequence V description binding site for residue JL2 A 401 source : AC1 8) chain A residue 115 type sequence E description binding site for residue JL2 A 401 source : AC1 9) chain A residue 116 type sequence Y description binding site for residue JL2 A 401 source : AC1 10) chain A residue 117 type sequence I description binding site for residue JL2 A 401 source : AC1 11) chain A residue 118 type sequence N description binding site for residue JL2 A 401 source : AC1 12) chain A residue 119 type sequence N description binding site for residue JL2 A 401 source : AC1 13) chain A residue 164 type sequence M description binding site for residue JL2 A 401 source : AC1 14) chain A residue 175 type sequence I description binding site for residue JL2 A 401 source : AC1 15) chain A residue 176 type sequence D description binding site for residue JL2 A 401 source : AC1 16) chain A residue 133 type sequence D description binding site for residue EDO A 402 source : AC2 17) chain A residue 136 type sequence F description binding site for residue EDO A 402 source : AC2 18) chain A residue 137 type sequence Y description binding site for residue EDO A 402 source : AC2 19) chain A residue 167 type sequence H description binding site for residue EDO A 402 source : AC2 20) chain A residue 170 type sequence K description binding site for residue EDO A 402 source : AC2 21) chain A residue 69 type sequence K description binding site for residue CL A 403 source : AC3 22) chain A residue 176 type sequence D description binding site for residue CL A 403 source : AC3 23) chain A residue 322 type sequence H description binding site for residue CL A 404 source : AC4 24) chain A residue 157 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 46 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 69 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 18 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 13 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 21 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 30) chain A residue 288 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 31) chain A residue 97 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI6 32) chain A residue 46-69 type prosite sequence LGRGKYSEVFEAINITNNERVVVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK source prosite : PS00107 33) chain A residue 153-165 type prosite sequence IMHRDVKPHNVMI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI source prosite : PS00108

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