eF-site ID 6qtp-ABCD PDB Code 6qtp Chain A, B, C, D click to enlarge Title 2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA Classification ISOMERASE Compound DNA gyrase subunit B,DNA gyrase subunit B Source (6QTP) Sequence A:  ERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRIL YGLNEQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAM VRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMTK ITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLAN GASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELM EDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIE RQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDE TSLRTGVRVVIDVRKASVILNNLYKQTPLQTSFGVNMIAL VNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKDRA HILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLS EKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETI LADEEVLLQLVRDELTEIRDRFGDDRRTEIQLG B:  GKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAIL PLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDL AKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAG YVYIAQPPYKGLGEMNADQLWETTMNPEHRALLQVKLEDA IEADQTFEMLMGDVVENRRQFIEDNAVYA C:  NERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRI LYGLNEQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEA MVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMT KITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLA NGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAEL MEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVI EERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGI TDLRDETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQT SFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQY NLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAME SLQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELL NYISELETILADEEVLLQLVRDELTEIRDRFGDDRRTEIQ L D:  KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILP LRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLA KARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGY VYIAQPPTGYKGLGEMNADQLWETTMNPEHRALLQVKLED AIEADQTFEMLMGDVVENRRQFIEDNAVYA Description Functional site 1) chain B residue 435 type sequence E description binding site for residue MN B 701 source : AC1 2) chain B residue 508 type sequence D description binding site for residue MN B 701 source : AC1 3) chain B residue 510 type sequence D description binding site for residue MN B 701 source : AC1 4) chain B residue 427 type sequence E description binding site for residue NA B 702 source : AC2 5) chain B residue 428 type sequence E description binding site for residue NA B 702 source : AC2 6) chain A residue 96 type sequence D description binding site for residue GOL A 501 source : AC3 7) chain A residue 97 type sequence F description binding site for residue GOL A 501 source : AC3 8) chain A residue 113 type sequence M description binding site for residue GOL A 501 source : AC3 9) chain A residue 219 type sequence P description binding site for residue GOL A 501 source : AC3 10) chain A residue 220 type sequence T description binding site for residue GOL A 501 source : AC3 11) chain A residue 485 type sequence R description binding site for residue GOL A 501 source : AC3 12) chain A residue 123 type sequence Y description binding site for residue MN D 701 source : AC4 13) chain D residue 435 type sequence E description binding site for residue MN D 701 source : AC4 14) chain D residue 508 type sequence D description binding site for residue MN D 701 source : AC4 15) chain A residue 429 type sequence R description binding site for residue SO4 C 501 source : AC5 16) chain C residue 429 type sequence R description binding site for residue SO4 C 501 source : AC5 17) chain A residue 68 type sequence A description binding site for residue JHN E 101 source : AC6 18) chain A residue 75 type sequence M description binding site for residue JHN E 101 source : AC6 19) chain A residue 83 type sequence D description binding site for residue JHN E 101 source : AC6 20) chain A residue 121 type sequence M description binding site for residue JHN E 101 source : AC6 21) chain C residue 68 type sequence A description binding site for residue JHN E 101 source : AC6 22) chain C residue 75 type sequence M description binding site for residue JHN E 101 source : AC6 23) chain C residue 83 type sequence D description binding site for residue JHN E 101 source : AC6 24) chain C residue 121 type sequence M description binding site for residue JHN E 101 source : AC6 25) chain B residue 433-441 type prosite sequence LVEGDSAGG description TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG source prosite : PS00177 26) chain A residue 123 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI1 27) chain C residue 123 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 510 type ACT_SITE sequence D description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 435 type ACT_SITE sequence E description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 508 type ACT_SITE sequence D description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 510 type ACT_SITE sequence D description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 460 type SITE sequence K description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 463 type SITE sequence N description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2 34) chain D residue 460 type SITE sequence K description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 463 type SITE sequence N description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links