eF-site ID 6qtp-ABCD
PDB Code 6qtp
Chain A, B, C, D

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Title 2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA
Classification ISOMERASE
Compound DNA gyrase subunit B,DNA gyrase subunit B
Source (6QTP)
Sequence A:  ERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRIL
YGLNEQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAM
VRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMTK
ITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLAN
GASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELM
EDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIE
RQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDE
TSLRTGVRVVIDVRKASVILNNLYKQTPLQTSFGVNMIAL
VNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKDRA
HILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLS
EKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETI
LADEEVLLQLVRDELTEIRDRFGDDRRTEIQLG
B:  GKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAIL
PLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDL
AKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAG
YVYIAQPPYKGLGEMNADQLWETTMNPEHRALLQVKLEDA
IEADQTFEMLMGDVVENRRQFIEDNAVYA
C:  NERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRI
LYGLNEQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEA
MVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMT
KITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLA
NGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAEL
MEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVI
EERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGI
TDLRDETSLRTGVRVVIDVRKDANASVILNNLYKQTPLQT
SFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQY
NLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAME
SLQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELL
NYISELETILADEEVLLQLVRDELTEIRDRFGDDRRTEIQ
L
D:  KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILP
LRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLA
KARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGY
VYIAQPPTGYKGLGEMNADQLWETTMNPEHRALLQVKLED
AIEADQTFEMLMGDVVENRRQFIEDNAVYA
Description


Functional site

1) chain B
residue 435
type
sequence E
description binding site for residue MN B 701
source : AC1

2) chain B
residue 508
type
sequence D
description binding site for residue MN B 701
source : AC1

3) chain B
residue 510
type
sequence D
description binding site for residue MN B 701
source : AC1

4) chain B
residue 427
type
sequence E
description binding site for residue NA B 702
source : AC2

5) chain B
residue 428
type
sequence E
description binding site for residue NA B 702
source : AC2

6) chain A
residue 96
type
sequence D
description binding site for residue GOL A 501
source : AC3

7) chain A
residue 97
type
sequence F
description binding site for residue GOL A 501
source : AC3

8) chain A
residue 113
type
sequence M
description binding site for residue GOL A 501
source : AC3

9) chain A
residue 219
type
sequence P
description binding site for residue GOL A 501
source : AC3

10) chain A
residue 220
type
sequence T
description binding site for residue GOL A 501
source : AC3

11) chain A
residue 485
type
sequence R
description binding site for residue GOL A 501
source : AC3

12) chain A
residue 123
type
sequence Y
description binding site for residue MN D 701
source : AC4

13) chain D
residue 435
type
sequence E
description binding site for residue MN D 701
source : AC4

14) chain D
residue 508
type
sequence D
description binding site for residue MN D 701
source : AC4

15) chain A
residue 429
type
sequence R
description binding site for residue SO4 C 501
source : AC5

16) chain C
residue 429
type
sequence R
description binding site for residue SO4 C 501
source : AC5

17) chain A
residue 68
type
sequence A
description binding site for residue JHN E 101
source : AC6

18) chain A
residue 75
type
sequence M
description binding site for residue JHN E 101
source : AC6

19) chain A
residue 83
type
sequence D
description binding site for residue JHN E 101
source : AC6

20) chain A
residue 121
type
sequence M
description binding site for residue JHN E 101
source : AC6

21) chain C
residue 68
type
sequence A
description binding site for residue JHN E 101
source : AC6

22) chain C
residue 75
type
sequence M
description binding site for residue JHN E 101
source : AC6

23) chain C
residue 83
type
sequence D
description binding site for residue JHN E 101
source : AC6

24) chain C
residue 121
type
sequence M
description binding site for residue JHN E 101
source : AC6

25) chain B
residue 433-441
type prosite
sequence LVEGDSAGG
description TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG
source prosite : PS00177

26) chain A
residue 123
type ACT_SITE
sequence Y
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897
source Swiss-Prot : SWS_FT_FI1

27) chain C
residue 123
type ACT_SITE
sequence Y
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897
source Swiss-Prot : SWS_FT_FI1

28) chain B
residue 510
type ACT_SITE
sequence D
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897
source Swiss-Prot : SWS_FT_FI1

29) chain D
residue 435
type ACT_SITE
sequence E
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897
source Swiss-Prot : SWS_FT_FI1

30) chain D
residue 508
type ACT_SITE
sequence D
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897
source Swiss-Prot : SWS_FT_FI1

31) chain D
residue 510
type ACT_SITE
sequence D
description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897
source Swiss-Prot : SWS_FT_FI1

32) chain B
residue 460
type SITE
sequence K
description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898
source Swiss-Prot : SWS_FT_FI2

33) chain B
residue 463
type SITE
sequence N
description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898
source Swiss-Prot : SWS_FT_FI2

34) chain D
residue 460
type SITE
sequence K
description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898
source Swiss-Prot : SWS_FT_FI2

35) chain D
residue 463
type SITE
sequence N
description Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898
source Swiss-Prot : SWS_FT_FI2


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