Title
|
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles |
Classification
|
RIBOSOME |
Compound
|
25S rRNA |
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
Sequence
|
B: |
GRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYI
RGIVKQIVHDSGRGAPLAKVVFRDPYKYRLREEIFIANEG
VHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKPG
DRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSD
ARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRG
VAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAAR
RTGLLRG
|
C: |
SHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPV
ALTSFLGYKAGMTTIVRDLDRPGSKFHKREVVEAVTVVDT
PPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKN
WYKSKKKAFTKYSAKYAQDGAGIERELARIKKYASVVRVL
VHTQIRKTPLAQKKAHLAEIQLNGGSISEKVDWAREHFEK
TVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPRK
THRGLRKVACIGAWHPAHVMWSVARAGQRGYHSRTSINHK
IYRVGKGDDEANGATSFDRTKKTITPMGGFVHYGEIKNDF
IMVKGCIPGNRKRIVTLRKSLYTNTSRKALEEVSLKWIDT
ASKFGKGRFQTPAEKHAFMGT
|
D: |
SRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTS
VNKNKRQAYAVSEKAGHQTSAESWGTGRAVARIPRVGGGG
TGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRYA
TASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQK
TKEAVAALKAVGAHSDLLKVLKSKKLRAGKGKYRNRRWTQ
RRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAPG
AHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHII
STSDVTRIINSSEIQSAIRPAGQATQKRTHVLKKNPLKNK
QVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFTETLKH
D
|
E: |
QNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQTP
VQSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLK
VKEYQLRDRNFSATGNFGFGIDEHIDLGIKYDPSIGIFGM
DFYVVMNRPGARVTRRKRCKGTVGNSHKTTKEDTVSWFKQ
KYDADVLDK
|
F: |
MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKH
IDVTFTKVNNQLIKVAVHNGGRKHVAALRTVKSLVDNMIT
GVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGD
KKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAAD
LQQICRVRNKDIRKFLDGIYVSHKGFITE
|
G: |
SAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLI
LLAGRFRGKRVVYLKHLEDNTLLISGPFKVNGVPLRRVNA
RYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEANL
FPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLSA
SFSLKNGDKPHMLKF
|
H: |
PLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQRQKKI
LSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAE
KKERLTKEAAAVAEGKSKQDASPKPYAVKYGLNHVVALIE
NKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIVKGKA
RLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFAD
KYDEVKKHWGGGILGNKAQAKMD
|
J: |
SQPVVVIDAKDHLLGRLASTIAKQVLNGQKIVVVRAEALN
ISGEFFRNKLKYHDFLRKATAFNKTRGPFHFRAPSRILYK
AIRGMVSHKTARGKAALERLKIFEGIPPPYDKKKRVVVPQ
ALRVLRLKPGRKYTTLGKLSTSVGWKYEDVVAKLEDKRKV
RSAEYYAKKRAFTKKVSSASAAASESDVAKQLASFGY
|
K: |
AISKNLPILKNHFRKHWQERVKVHFDQAGKKVSRRNARAT
RAAKIAPRPLDLLRPVVRAPTVKYNRKVRAGRGFTLAEVK
AAGLTAAYARTIGIAVDHRRQNRNQEIFDANVQRLKEYQS
KIIVFPRNGKAPEAEQVLSAAATFPIAQPATDVEARAVQD
NGESAFRTLRLARSEKKFRGIREKRA
|
L: |
SGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKG
SGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQ
AKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKE
CADLWPRVASNSGVVV
|
M: |
STDSIVKASNWRLVEVGRVVLIKKGQSAGKLAAIVEIIDQ
KKVLIDGPKAGVPRQAINLGQVVLTPLTFALPRGARTATV
SKKWAAAAVCEKWAASSWAKKIAQRERRAALTDFERFQVM
VLRKQKRYTVKKALAKA
|
N: |
PSRFTKTRKHRGHVSAGKGRIGKHRKHPGGRGMAGGQHHH
RINMDKYHPGYFGKVGMRYFHKQQAHFWKPVLNLDKLWTL
IPEDKRDQYLKSASKETAPVIDTLAAGYGKILGKGRIPNV
PVIVKARFVSKLAEEKIRAAGGVVELIA
|
O: |
GAYKYLEELQRKKQSDVLRFLQRVRVWEYRQKNVIHRAAR
PTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATY
GKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWV
NQDSTYKYFEVILVDPQHKAIRRDARYNWICDPVHKHREA
RGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWR
YRK
|
P: |
KSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTP
KYRLVVRFTNKDIICQIISSTITGDVVLAAAYSHELPRYG
ITHGLTNWAAAYATGLLIARRTLQKLGLDETYKGVEEVEG
EYELTEAVEDGPRPFKVFLDIGLQRTTTGARVFGALKGAS
DGGLYVPHSENRFPGWDFETEEIDPELLRSYIFGGHVSQY
MEELADDDEERFSELFKGYLADDIDADSLEDIYTSAHEAI
RADPAFKPTEKKFTKEQYAAESKKYRQTKLSKEERAARVA
AKIAAL
|
Q: |
GIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTD
APFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTV
VVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGEC
ITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGK
APRILSTGRKFERARGRRRSKGFKV
|
R: |
ANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAI
RKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKR
KGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYH
VLYKESKGNAFKHKRALVEHIIQAKADAQR
|
S: |
MAHFKEYQVIGRRLPTESVPEPKLFRMRIFASNEVIAKSR
YWYFLQKLHKVKKASGEIVSINQINEAHPTKVKNFGVWVR
YDSRSGTHNMYKEIRDVSRVAAVETLYQDMAARHRARFRS
IHILKVAEIEKTADVKRQYVKQFLTKDLKFPLPHRVQKST
KTFSYKRPSTFY
|
T: |
GKSHGYRSRTRYMFQRDFRKHGAVHLSTYLKVYKVGDIVD
IKANGSIQKGMPHKFYQGKTGVVYNVTKSSVGVIINKMVG
NRYLEKRLNLRVEHIKHSKCRQEFLERVKANAAKRAEAKA
QGVAVQLKRQPAQPRESRIVSTEGNVPQTLAPVPYETFI
|
U: |
ARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWEL
TKAQKYLEQVLDHQRAIPFRRFNSSIGRTAQGKEFGVTKA
RWPAKSVKFVQGLLQNAAANAEAKGLDATKLYVSHIQVNQ
APKQRRRTYRAHGRINKYESSPSHIELVVTEKEE
|
V: |
IAKTFTVDVSSPTENGVFDPASYAKYLIDHIKVEGAVGNL
GNAVTVTEDGTVVTVVSTAKFSGKYLKYLTKKYLKKNQLR
DWIRFVSTKTNEYRLAFYQ
|
W: |
ALKVRTSATFRLPKTLKLARAPKYASKAVPHYNRLDSYKV
IEQPITSETAMKKVEDGNILVFQVSMKANKYQIKKAVKEL
YEVDVLKVNTLVRPNGTKKAYVRLTADYDALDIANRIGYI
|
X: |
AKQSLDVSSDRRKARKAYFTAPSSQRRVLLSAPLSKELRA
QYGIKALPIRRDDEVLVVRGSKKGQEGKISSVYRLKFAVQ
VDKVTKEKVNGASVPINLHPSKLVITKLHLDKDRKALIQR
KGGKL
|
Y: |
AKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKSHPFGHA
LVAGIERYPLKVTKKHGAKKVAKRTKIKPFIKVVNYNHLL
PTRYTLDVEAFKSVVSTETFEQPSQREEAKKVVKKAFEER
HQAGKNQWFFSKLRF
|
Z: |
AGVKAYELRTKSKEQLASQLVDLKKELAELKVQKLSRPSL
PKIKTVRKSIACVLTVINEQQREAVRQLYKGKKYQPKDLR
AKKTRALRRALTKFEASQVTEKQRKKQIAFPQRKYAIKA
|
a: |
SKNHTAHNQTRKAHRNGIKKPKTYKYPSLKGVDPKFRRNH
KHALHGTAKALAAA
|
b: |
VAAERAARKAANKEKRAIILERNAAYQKEYETAERNIIQA
KRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQL
LRLTRINSGTFVKVTKATLELLKLIEPYVAYGYPSYSTIR
QLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILSIDDLI
HEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQ
GGSFGNREEFINKLVKSMN
|
c: |
SINQKLALVIKSGKYTLGYKSTVKSLRQGKSKLIIIAANT
PVLRKSELEYYAMLSKTKVYYFQGGNNELGTAVGKLFRVG
VVSILEAGDSDILTTLA
|
d: |
DVVTREYTINLHKRLHGVSFKKRAPRAVKEIKKFAKLHMG
TDDVRLAPELNQAIWKRGVKGVEYRLRLRISRKRNEEEDA
KNPLFSYVEPVLVASAKGLQTVVVEED
|
e: |
PKIVKKHTKKFKRHHSDRYHRVAENWRKQKGIDSVVRRRF
RGNISQPKIGYGSNKKTKFLSPSGHKTFLVANVKDLETLT
MHTKTYAAEIAHNISAKNRVVILARAKALGIKVTNPKGRL
A
|
f: |
AESHRLYVKGKHLSYQRSKRVNNPNVSLIKIEGVATPQDA
QFYLGKRIAYVYRASKEVRGSKIRVMWGKVTRTHGNSGVV
RATFRNNLPAKTFGASVRIFLYPSNI
|
g: |
AQRVTFRRRNPYNTRSNKIKVVKTPGGILRAQHVKKLATR
PKCGDCGSALQGISTLRPRQYATVSKTHKTVSRAYGGSRC
ANCVKERIIRAFLIEEQKIVKKV
|
h: |
VKTGIAIGLNKGKKVTSMTPAPKISYKKGAASNRTKFVRS
LVREIAGLSPYERRLIDLIRNSGEKRARKVAKKRLGSFTR
AKAKVEEMNNIIAASRRH
|
i: |
GKGTPSFGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPA
AKTRSYNWGAKAKRRHTTGTGRMRYLKHVSRRFKNGFQTG
SASK
|
j: |
AREITDIKQFLELTRRADVKTATVKINKKLNKAGKPFRQT
KFKVRGSSSLYTLVINDAGKAKKLIQSLPPTLKVNRL
|
k: |
AAQKSFRIKQKMAKAKKQNRPLPQWIRLRTNNTIRYNAKR
RNWRRTKMNI
|
l: |
VNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKR
RYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRA
QLTLKRCKHFELGG
|
m: |
AKRTKKVGITGKYGVRYGSSLRRQVKKLEIQQHARYDCSF
CGKKTVKRGAAGIWTCSCCKKTVAGGAYTVSTAAAATVRS
TIRRLREMVEA
|
n: |
MATRTQFENSNEIGVFSKLTNTYCLVAVGGSENFYSAFEA
ELGDAIPIVHTTIAGTRIIGRMTAGNRRGLLVPTQTTDQE
LQHLRNSLPDSVKIQRVEERLSALGNVICCNDYVALVHPD
IDRETEELISDVLGVEVFRQTISGNILVGSYCSLSNQGGL
VHPQTSVQDQEELSSLLQVPLVAGTVNRGSSVVGAGMVVN
DYLAVTGLDTTAPELSVIESIFRL
|
q: |
ARRPARCYRYQKNKPYPKSRYNRAVPDSKIRIYDLGKKKA
TVDEFPLCVHLVSNELEQLSSEALEAARICANKYMTTVSG
RDAFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWGK
PHGLAARVDIGQIIFSVRTKDSNKDVVVEGLRRARYKFPG
QQKIILSKKWGFTNLDRPEYLKKREAGEVKDDGAFVKFLS
KKGSLENNIREFPEYF
|
t: |
IIEPSLKALASKYNCDKSVCRKCYARLPPRATNCRKRKCG
HTNQLRPKKKLK
|
v: |
MKVEIDSFSGAKIYPGRGTLFVRGDSKIFRFQNSKSASLF
KQRKNPRRIAWTVLFRKHHK
|
z: |
TAADRRMVSGVTEKQYKKGMKKMQQLEKNAINTQIRREIK
RVNFQTHYRDELL
|
|
Description
|
(1) |
60S ribosomal protein L2-A, 60S ribosomal protein L3, 60S ribosomal protein L4-A, 60S ribosomal protein L11-B, 60S ribosomal protein L9-A, 60S ribosomal protein L6-A, 60S ribosomal protein L8-A, 60S ribosomal protein L10, 60S ribosomal protein L16-B, 60S ribosomal protein L13-A, 60S ribosomal protein L23-A, 60S ribosomal protein L14-A, 60S ribosomal protein L28, 60S ribosomal protein L15-A, 60S ribosomal protein L5, 60S ribosomal protein L18-A, 60S ribosomal protein L19-A, 60S ribosomal protein L20-A, 60S ribosomal protein L21-A, 60S ribosomal protein L17-A, 60S ribosomal protein L22-A, 60S ribosomal protein L25, 60S ribosomal protein L26-A, 60S ribosomal protein L27-A, 60S ribosomal protein L35-A, eL29, 60S ribosomal protein L7-A, 60S ribosomal protein L30, 60S ribosomal protein L31-A, 60S ribosomal protein L32, 60S ribosomal protein L33-A, 60S ribosomal protein L34-A, 60S ribosomal protein L36-A, 60S ribosomal protein L37-A, 60S ribosomal protein L38, 60S ribosomal protein L39, 60S ribosomal protein L42-A, 60S ribosomal protein L43-A, Eukaryotic translation initiation factor 6, Ubiquitin-60S ribosomal protein L40, Ribosome biogenesis protein RLP24, Cytoplasmic 60S subunit biogenesis factor REH1/RNA Complex
|