eF-site ID 6qmj-A PDB Code 6qmj Chain A click to enlarge Title Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction Classification PROTEIN BINDING Compound Kelch-like ECH-associated protein 1 Source (KEAP1_MOUSE) Sequence A:  GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSG LAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWS PCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYE PERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRL NSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGG YDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQG KIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGV GVAVTMEPC Description (1)  Kelch-like ECH-associated protein 1 Functional site 1) chain A residue 435 type sequence I description binding site for residue SO4 A 701 source : AC1 2) chain A residue 437 type sequence H description binding site for residue SO4 A 701 source : AC1 3) chain A residue 438 type sequence S description binding site for residue SO4 A 701 source : AC1 4) chain A residue 439 type sequence S description binding site for residue SO4 A 701 source : AC1 5) chain A residue 494 type sequence R description binding site for residue SO4 A 701 source : AC1 6) chain A residue 414 type sequence N description binding site for residue CL A 702 source : AC2 7) chain A residue 334 type sequence Y description binding site for residue J6K A 703 source : AC3 8) chain A residue 363 type sequence S description binding site for residue J6K A 703 source : AC3 9) chain A residue 364 type sequence G description binding site for residue J6K A 703 source : AC3 10) chain A residue 382 type sequence N description binding site for residue J6K A 703 source : AC3 11) chain A residue 415 type sequence R description binding site for residue J6K A 703 source : AC3 12) chain A residue 478 type sequence F description binding site for residue J6K A 703 source : AC3 13) chain A residue 483 type sequence R description binding site for residue J6K A 703 source : AC3 14) chain A residue 508 type sequence S description binding site for residue J6K A 703 source : AC3 15) chain A residue 509 type sequence G description binding site for residue J6K A 703 source : AC3 16) chain A residue 525 type sequence Y description binding site for residue J6K A 703 source : AC3 17) chain A residue 530 type sequence Q description binding site for residue J6K A 703 source : AC3 18) chain A residue 555 type sequence S description binding site for residue J6K A 703 source : AC3 19) chain A residue 556 type sequence A description binding site for residue J6K A 703 source : AC3 20) chain A residue 572 type sequence Y description binding site for residue J6K A 703 source : AC3 21) chain A residue 602 type sequence S description binding site for residue J6K A 703 source : AC3 22) chain A residue 603 type sequence G description binding site for residue J6K A 703 source : AC3 23) chain A residue 434 type SITE sequence C description Sensor for electrophilic agents => ECO:0000269|PubMed:20498371 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 434 type MOD_RES sequence C description S-cGMP-cysteine => ECO:0000269|PubMed:20498371 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 613 type MOD_RES sequence C description S-(2-succinyl)cysteine => ECO:0000269|PubMed:22014577 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links