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eF-site ID
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6ql7-C |
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PDB Code
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6ql7 |
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Chain
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C |
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click to enlarge
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Title
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Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom |
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Classification
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TRANSFERASE |
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Compound
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Fatty acid synthase subunit alpha |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); |
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Sequence
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C: |
MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFN
TERVVEIGPSPTLAGMAQRTLKNKYESYDAALSLHREILC
YSKDAKEIYYTPDPSIADEPVKASLLLHVLVAHKLKKSLD
SIPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEET
PLEELAETFQDTFSGALGKQSSSLLSRLISSKMPGGFTIT
VARKYLQTRWGLPSGRQDGVLLVALSNEPAARLGSEADAK
AFLDSMAQKYASIVGVDLLEEITKDHKVLARQQLQVLARY
LKMDLDNGERKFLKEKDTVAELQAQLDYLNAELGEFFVNG
VATSFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVD
REVVSEAINIMNRSNDALIKFMEYHISNTDETKGENYQLV
KTLGEQLIENCKQVLDVDPVYKDVAKPTGPKTAIDKNGNI
TYSEEPREKVRKLSQYVQEMALGGPITKESQPMDVEDALD
KDSTKEVASLPNKSTISKTVSSTIPRETIPFLHLRKKTPA
GDWKYDRQLSSLFLDGLEKAAFNGVTFKDKYVLITGAGKG
SIGAEVLQGLLQGGAKVVVTTSRFSKQVTDYYQSIYAKYG
AKGSTLIVVPFNQGSKQDVEALIEFIYDTEKNGGLGWDLD
AIIPFAAIPEQGIELEHIDSKSEFAHRIMLTNILRMMGCV
KKQKSARGIETRPAQVILPMSPNHGTFGGDGMYSESKLSL
ETLFNRWHSESWANQLTVCGAIIGWTRGTGLMSANNIIAE
GIEKMGVRTFSQKEMAFNLLGLLTPEVVELCQKSPVMADL
NGGLQFVPELKEFTAKLRKELVETSEVRKAVSIETALEHK
VVNGNSADAAYAQVEIQPRANIQLDFPELKPYKQVKQIAP
AELEGLLDLERVIVVTGFAEVGPWGSARTRWEMEAFGEFS
LEGCVEMAWIMGFISYHNGNLKGRPYTGWVDSKTKEPVDD
KDVKAKYETSILEHSGIRLIEPELFNGYNPEKKEMIQEVI
VEEDLEPFEASKETAEQFKHQHGDKVDIFEIPETGEYSVK
LLKGATLYIPKALRFDRLVAGQIPTGWNAKTYGISDDIIS
QVDPITLFVLVSVVEAFIASGITDPYEMYKYVHVSEVGNC
SGSGMGGVSALRGMFKDRFKDEPVQNDILQESFINTMSAW
VNMLLISSSGPIKTPVGACATSVESVDIGVETILSGKARI
CIVGGYDDFQEEGSFEFGNMKATSNTLEEFEHGRTPAEMS
RPATTTRNGFMEAQGAGIQIIMQADLALKMGVPIYGIVAM
AATATDKIGRSVPAPGKGILTTAREHHSSVKYASPNLNMK
YRKRQLVTREAQIKDWVENELEALKLEAEEIPSEDQNEFL
LERTREIHNEAESQLRAAQQQWGNDFYKRDPRIAPLRGAL
ATYGLTIDDLGVASFHGTSTKANDKNESATINEMMKHLGR
SEGNPVIGVFQKFLTGHPKGAAGAWMMNGALQILNSGIIP
GNRNADNVDKILEQFEYVLYPSKTLKTDGVRAVSITSFGF
GQKGGQAIVVHPDYLYGAITEDRYNEYVAKVSAREKSAYK
FFHNGMIYNKLFVSKEHAPYTDELEEDVYLDPLARVSKDK
KSGSLTFNSKNIQSKDSYINANTIETAKMIENMTKEKVSN
GGVGVDVELITSINVENDTFIERNFTPQEIEYCSAQPSVQ
SSFAGTWSAKEAVFKSLGVKSLGGGAALKDIEIVRVNKNA
PAVELHGNAKKAAEEAGVTDVKVSISHDDLQAVAVAVSTK
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Description
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(1) |
Fatty acid synthase subunit alpha (E.C.2.3.1.86,1.1.1.100,2.3.1.41), Fatty acid synthase subunit beta (E.C.2.3.1.86,4.2.1.59,1.3.1.9,2.3.1.38,2.3.1.39,3.1.2.14), Translation machinery-associated protein 17
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Functional site
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1)
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chain |
C |
| residue |
37 |
| type |
CROSSLNK |
| sequence |
K
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| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
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| source |
Swiss-Prot : SWS_FT_FI8
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2)
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chain |
C |
| residue |
1772 |
| type |
MOD_RES |
| sequence |
D
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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3)
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chain |
C |
| residue |
1773 |
| type |
MOD_RES |
| sequence |
V
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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4)
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chain |
C |
| residue |
1774 |
| type |
MOD_RES |
| sequence |
E
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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5)
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chain |
C |
| residue |
1817 |
| type |
MOD_RES |
| sequence |
E
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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6)
|
chain |
C |
| residue |
1841 |
| type |
MOD_RES |
| sequence |
R
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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7)
|
chain |
C |
| residue |
1871 |
| type |
MOD_RES |
| sequence |
I
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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8)
|
chain |
C |
| residue |
1872 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI2
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9)
|
chain |
C |
| residue |
1873 |
| type |
MOD_RES |
| sequence |
H
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI2
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10)
|
chain |
C |
| residue |
958 |
| type |
MOD_RES |
| sequence |
S
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950
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| source |
Swiss-Prot : SWS_FT_FI7
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11)
|
chain |
C |
| residue |
1440 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950
|
| source |
Swiss-Prot : SWS_FT_FI7
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