eF-site ID 6ql6-A PDB Code 6ql6 Chain A click to enlarge Title Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom Classification TRANSFERASE Compound Fatty acid synthase subunit alpha Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence A:  MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFN TERVVEIGPSPTLAGMAQRTLKNKYESYDAALSLHREILC YSKDAKEIYYTPDPIADEPVKASLLLHVLVAHKLKKSLDS IPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEETP LEELAETFQDTFSGALGKQSSSLLSRLISSKMPGGFTITV ARKYLQTRWGLPSGRQDGVLLVALSNEPAARLGSEADAKA FLDSMAQKYASIVGVDLLEEITKDHKVLARQQLQVLARYL KMDLDNGERKFLKEKDTVAELQAQLDYLNAELGEFFVNGV ATSFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVDR EVVSEAINIMNRSNDALIKFMEYHISNTDETKGENYQLVK TLGEQLIENCKQVLDVDPVYKDVAKPTGPKTAIDKNGNIT YSEEPREKVRKLSQYVQEMALGGPITKESMDVEDALDKDS TKEVASLPNKSTISKTVSSTIPRETIPFLHLRKKTPAGDW KYDRQLSSLFLDGLEKAAFNGVTFKDKYVLITGAGKGSIG AEVLQGLLQGGAKVVVTTSRFSKQVTDYYQSIYAKYGAKG STLIVVPFNQGSKQDVEALIEFIYDTEKNGGLGWDLDAII PFAAIPEQGIELEHIDSKSEFAHRIMLTNILRMMGCVKKQ KSARGIETRPAQVILPMSPNHGTFGGDGMYSESKLSLETL FNRWHSESWANQLTVCGAIIGWTRGTGLMSANNIIAEGIE KMGVRTFSQKEMAFNLLGLLTPEVVELCQKSPVMADLNGG LQFVPELKEFTAKLRKELVETSEVRKAVSIETALEHKVVN GNSADAAYAQVEIQPRANIQLDFPELKPYKQVKQIAPAEL EGLLDLERVIVVTGFAEVGPWGSARTRWEMEAFGEFSLEG CVEMAWIMGFISYHNGNLKGRPYTGWVDSKTKEPVDDKDV KAKYETSILEHSGIRLIEPELFNGYNPEKKEMIQEVIVEE DLEPFEASKETAEQFKHQHGDKVDIFEIPETGEYSVKLLK GATLYIPKALRFDRLVAGQIPTGWNAKTYGISDDIISQVD PITLFVLVSVVEAFIASGITDPYEMYKYVHVSEVGNCSGS GMGGVSALRGMFKDRFKDEPVQNDILQESFINTMSAWVNM LLISSSGPIKTPVGACATSVESVDIGVETILSGKARICIV GGYDDFQEEGSFEFGNMKATSNTLEEFEHGRTPAEMSRPA TTTRNGFMEAQGAGIQIIMQADLALKMGVPIYGIVAMAAT ATDKIGRSVPAPGKGILTTAREHHSSVKYASPNLNMKYRK RQLVTREAQIKDWVENELEALKLEAEEIPSEDQNEFLLER TREIHNEAESQLRAAQQQWGNDFYKRDPRIAPLRGALATY GLTIDDLGVASFHGTSTKANDKNESATINEMMKHLGRSEG NPVIGVFQKFLTGHPKGAAGAWMMNGALQILNSGIIPGNR NADNVDKILEQFEYVLYPSKTLKTDGVRAVSITSFGFGQK GGQAIVVHPDYLYGAITEDRYNEYVAKVSAREKSAYKFFH NGMIYNKLFVSKEHAPYTDELEEDVYLDPLARVSKDKKSG SLTFNSKNIQSKDSYINANTIETAKMIENMTKEKVSNGGV GVDVELITSINVENDTFIERNFTPQEIEYCSAQPSVQSSF AGTWSAKEAVFKSLGVKSLGGGAALKDIEIVRVNKNAPAV ELHGNAKKAAEEAGVTDVKVSISHDDLQAVAVAVSTK Description (1)  Fatty acid synthase subunit alpha (E.C.2.3.1.86,1.1.1.100,2.3.1.41), Fatty acid synthase subunit beta (E.C.2.3.1.86,4.2.1.59,1.3.1.9,2.3.1.38,2.3.1.39,3.1.2.14) Functional site 1) chain A residue 180 type sequence S description binding site for residue J8T A 1901 source : AC1 2) chain A residue 1417 type sequence S description binding site for Di-peptide J8T F 1901 and SER F 180 source : AD3 3) chain A residue 1419 type sequence P description binding site for Di-peptide J8T F 1901 and SER F 180 source : AD3 4) chain A residue 1420 type sequence A description binding site for Di-peptide J8T F 1901 and SER F 180 source : AD3 5) chain A residue 1548 type sequence A description binding site for Di-peptide J8T F 1901 and SER F 180 source : AD3 6) chain A residue 37 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI8 7) chain A residue 1296-1312 type prosite sequence GPIKTPVGACATSVESV description KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV source prosite : PS00606 8) chain A residue 175-190 type prosite sequence LVGGKSTVQNEILGDL description PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL source prosite : PS00012 9) chain A residue 1872 type ACT_SITE sequence S description For malonyltransferase activity => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 1873 type ACT_SITE sequence H description For malonyltransferase activity => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 523 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI6 12) chain A residue 958 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17330950 source Swiss-Prot : SWS_FT_FI7 13) chain A residue 1440 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17330950 source Swiss-Prot : SWS_FT_FI7

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