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eF-site ID
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6ql5-B |
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PDB Code
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6ql5 |
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Chain
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B |
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click to enlarge
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Title
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Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 2.8 angstrom |
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Classification
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TRANSFERASE |
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Compound
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Fatty acid synthase subunit alpha |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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B: |
MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFN
TERVVEIGPSPTLAGMAQRTLKNKYESYDAALSLHREILC
YSKDAKEIYYTPDPIADEPVKASLLLHVLVAHKLKKSLDS
IPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEETP
LEELAETFQDTFSGALGKQSSSLLSRLISSKMPGGFTITV
ARKYLQTRWGLPSGRQDGVLLVALSNEPAARLGSEADAKA
FLDSMAQKYASIVGVDLLEEITKDHKVLARQQLQVLARYL
KMDLDNGERKFLKEKDTVAELQAQLDYLNAELGEFFVNGV
ATSFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVDR
EVVSEAINIMNRSNDALIKFMEYHISNTDETKGENYQLVK
TLGEQLIENCKQVLDVDPVYKDVAKPTGPKTAIDKNGNIT
YSEEPREKVRKLSQYVQEMALGGPITKESALDKDSTKEVA
SLPNKSTISKTVSSTIPRETIPFLHLRKKTPAGDWKYDRQ
LSSLFLDGLEKAAFNGVTFKDKYVLITGAGKGSIGAEVLQ
GLLQGGAKVVVTTSRFSKQVTDYYQSIYAKYGAKGSTLIV
VPFNQGSKQDVEALIEFIYDTEKNGGLGWDLDAIIPFAAI
PEQGIELEHIDSKSEFAHRIMLTNILRMMGCVKKQKSARG
IETRPAQVILPMSPNHGTFGGDGMYSESKLSLETLFNRWH
SESWANQLTVCGAIIGWTRGTGLMSANNIIAEGIEKMGVR
TFSQKEMAFNLLGLLTPEVVELCQKSPVMADLNGGLQFVP
ELKEFTAKLRKELVETSEVRKAVSIETALEHKVVNGNSAD
AAYAQVEIQPRANIQLDFPELKPYKQVKQIAPAELEGLLD
LERVIVVTGFAEVGPWGSARTRWEMEAFGEFSLEGCVEMA
WIMGFISYHNGNLKGRPYTGWVDSKTKEPVDDKDVKAKYE
TSILEHSGIRLIEPELFNGYNPEKKEMIQEVIVEEDLEPF
EASKETAEQFKHQHGDKVDIFEIPETGEYSVKLLKGATLY
IPKALRFDRLVAGQIPTGWNAKTYGISDDIISQVDPITLF
VLVSVVEAFIASGITDPYEMYKYVHVSEVGNCSGSGMGGV
SALRGMFKDRFKDEPVQNDILQESFINTMSAWVNMLLISS
SGPIKTPVGACATSVESVDIGVETILSGKARICIVGGYDD
FQEEGSFEFGNMKATSNTLEEFEHGRTPAEMSRPATTTRN
GFMEAQGAGIQIIMQADLALKMGVPIYGIVAMAATATDKI
GRSVPAPGKGILTTAREHHSSVKYASPNLNMKYRKRQLVT
REAQIKDWVENELEALKLEAEEIPSEDQNEFLLERTREIH
NEAESQLRAAQQQWGNDFYKRDPRIAPLRGALATYGLTID
DLGVASFHGTSTKANDKNESATINEMMKHLGRSEGNPVIG
VFQKFLTGHPKGAAGAWMMNGALQILNSGIIPGNRNADNV
DKILEQFEYVLYPSKTLKTDGVRAVSITSFGFGQKGGQAI
VVHPDYLYGAITEDRYNEYVAKVSAREKSAYKFFHNGMIY
NKLFVSKEHAPYTDELEEDVYLDPLARVSKDKKSGSLTFN
SKNIQSKDSYINANTIETAKMIENMTKEKVSNGGVGVDVE
LITSINVENDTFIERNFTPQEIEYCSAQPSVQSSFAGTWS
AKEAVFKSLGVKSLGGGAALKDIEIVRVNKNAPAVELHGN
AKKAAEEAGVTDVKVSISHDDLQAVAVAVSTK
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Description
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(1) |
Fatty acid synthase subunit alpha (E.C.2.3.1.86,1.1.1.100,2.3.1.41), Fatty acid synthase subunit beta (E.C.2.3.1.86,4.2.1.59,1.3.1.9,2.3.1.38,2.3.1.39,3.1.2.14), Translation machinery-associated protein 17
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Functional site
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1)
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chain |
B |
| residue |
180 |
| type |
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| sequence |
S
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| description |
binding site for residue PNS B 1901
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| source |
: AC2
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2)
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chain |
B |
| residue |
37 |
| type |
CROSSLNK |
| sequence |
K
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| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
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| source |
Swiss-Prot : SWS_FT_FI8
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3)
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chain |
B |
| residue |
1773 |
| type |
MOD_RES |
| sequence |
V
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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|
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4)
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chain |
B |
| residue |
1774 |
| type |
MOD_RES |
| sequence |
E
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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5)
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chain |
B |
| residue |
1817 |
| type |
MOD_RES |
| sequence |
E
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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6)
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chain |
B |
| residue |
1841 |
| type |
MOD_RES |
| sequence |
R
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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7)
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chain |
B |
| residue |
1871 |
| type |
MOD_RES |
| sequence |
I
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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8)
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chain |
B |
| residue |
1872 |
| type |
MOD_RES |
| sequence |
S
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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|
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9)
|
chain |
B |
| residue |
1873 |
| type |
MOD_RES |
| sequence |
H
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI2
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10)
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chain |
B |
| residue |
1772 |
| type |
MOD_RES |
| sequence |
D
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI2
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11)
|
chain |
B |
| residue |
180 |
| type |
CROSSLNK |
| sequence |
S
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
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| source |
Swiss-Prot : SWS_FT_FI5
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|
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12)
|
chain |
B |
| residue |
523 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:19779198
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| source |
Swiss-Prot : SWS_FT_FI6
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13)
|
chain |
B |
| residue |
958 |
| type |
MOD_RES |
| sequence |
S
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| description |
Phosphoserine => ECO:0007744|PubMed:17330950
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| source |
Swiss-Prot : SWS_FT_FI7
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14)
|
chain |
B |
| residue |
1440 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950
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| source |
Swiss-Prot : SWS_FT_FI7
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