eF-site ID 6ql5-A PDB Code 6ql5 Chain A click to enlarge Title Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 2.8 angstrom Classification TRANSFERASE Compound Fatty acid synthase subunit alpha Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence A:  MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFN TERVVEIGPSPTLAGMAQRTLKNKYESYDAALSLHREILC YSKDAKEIYYTPDPIADEPVKASLLLHVLVAHKLKKSLDS IPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEETP LEELAETFQDTFSGALGKQSSSLLSRLISSKMPGGFTITV ARKYLQTRWGLPSGRQDGVLLVALSNEPAARLGSEADAKA FLDSMAQKYASIVGVDLLEEITKDHKVLARQQLQVLARYL KMDLDNGERKFLKEKDTVAELQAQLDYLNAELGEFFVNGV ATSFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVDR EVVSEAINIMNRSNDALIKFMEYHISNTDETKGENYQLVK TLGEQLIENCKQVLDVDPVYKDVAKPTGPKTAIDKNGNIT YSEEPREKVRKLSQYVQEMALGGPITKESALDKDSTKEVA SLPNKSTISKTVSSTIPRETIPFLHLRKKTPAGDWKYDRQ LSSLFLDGLEKAAFNGVTFKDKYVLITGAGKGSIGAEVLQ GLLQGGAKVVVTTSRFSKQVTDYYQSIYAKYGAKGSTLIV VPFNQGSKQDVEALIEFIYDTEKNGGLGWDLDAIIPFAAI PEQGIELEHIDSKSEFAHRIMLTNILRMMGCVKKQKSARG IETRPAQVILPMSPNHGTFGGDGMYSESKLSLETLFNRWH SESWANQLTVCGAIIGWTRGTGLMSANNIIAEGIEKMGVR TFSQKEMAFNLLGLLTPEVVELCQKSPVMADLNGGLQFVP ELKEFTAKLRKELVETSEVRKAVSIETALEHKVVNGNSAD AAYAQVEIQPRANIQLDFPELKPYKQVKQIAPAELEGLLD LERVIVVTGFAEVGPWGSARTRWEMEAFGEFSLEGCVEMA WIMGFISYHNGNLKGRPYTGWVDSKTKEPVDDKDVKAKYE TSILEHSGIRLIEPELFNGYNPEKKEMIQEVIVEEDLEPF EASKETAEQFKHQHGDKVDIFEIPETGEYSVKLLKGATLY IPKALRFDRLVAGQIPTGWNAKTYGISDDIISQVDPITLF VLVSVVEAFIASGITDPYEMYKYVHVSEVGNCSGSGMGGV SALRGMFKDRFKDEPVQNDILQESFINTMSAWVNMLLISS SGPIKTPVGACATSVESVDIGVETILSGKARICIVGGYDD FQEEGSFEFGNMKATSNTLEEFEHGRTPAEMSRPATTTRN GFMEAQGAGIQIIMQADLALKMGVPIYGIVAMAATATDKI GRSVPAPGKGILTTAREHHSSVKYASPNLNMKYRKRQLVT REAQIKDWVENELEALKLEAEEIPSEDQNEFLLERTREIH NEAESQLRAAQQQWGNDFYKRDPRIAPLRGALATYGLTID DLGVASFHGTSTKANDKNESATINEMMKHLGRSEGNPVIG VFQKFLTGHPKGAAGAWMMNGALQILNSGIIPGNRNADNV DKILEQFEYVLYPSKTLKTDGVRAVSITSFGFGQKGGQAI VVHPDYLYGAITEDRYNEYVAKVSAREKSAYKFFHNGMIY NKLFVSKEHAPYTDELEEDVYLDPLARVSKDKKSGSLTFN SKNIQSKDSYINANTIETAKMIENMTKEKVSNGGVGVDVE LITSINVENDTFIERNFTPQEIEYCSAQPSVQSSFAGTWS AKEAVFKSLGVKSLGGGAALKDIEIVRVNKNAPAVELHGN AKKAAEEAGVTDVKVSISHDDLQAVAVAVSTK Description (1)  Fatty acid synthase subunit alpha (E.C.2.3.1.86,1.1.1.100,2.3.1.41), Fatty acid synthase subunit beta (E.C.2.3.1.86,4.2.1.59,1.3.1.9,2.3.1.38,2.3.1.39,3.1.2.14), Translation machinery-associated protein 17 Functional site 1) chain A residue 180 type sequence S description binding site for residue PNS A 1901 source : AC1 2) chain A residue 958 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17330950 source Swiss-Prot : SWS_FT_FI7 3) chain A residue 1440 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17330950 source Swiss-Prot : SWS_FT_FI7 4) chain A residue 1296-1312 type prosite sequence GPIKTPVGACATSVESV description KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV source prosite : PS00606 5) chain A residue 175-190 type prosite sequence LVGGKSTVQNEILGDL description PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL source prosite : PS00012 6) chain A residue 1872 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 1873 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 523 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI6 9) chain A residue 37 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI8

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