eF-site ID 6qib-APT PDB Code 6qib Chain A, P, T click to enlarge Title The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster Classification DNA BINDING PROTEIN Compound DNA polymerase epsilon catalytic subunit A Source (6QIB) Sequence A:  ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDID QIPGRVGWLTNMHATLVSQEQGISGVDFYFLDEEGGSFKS TVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIR KEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQ DNANNNVQRNIYNVVDAKHLIEDIREYDVPYHVRVSIDKD IRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPL KFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYT PKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFN GDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCS HMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPEL MTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCT IIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDP IERFYDGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDP SAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQIT QKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDS IKAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYN MIKRALQNETFPNKKKKVLTFDELSYADQVIHIKKRLTEY SRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRY EFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLA HKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMAR ALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLY LSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTI FFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELK GFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASV CNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQ KSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPV TERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIID WGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKR KIA P:  TAACCGCGTTX T:  TCTTGAACGCGGTTA Description Functional site 1) chain A residue 665 type sequence C description binding site for residue SF4 A 1201 source : AC1 2) chain A residue 668 type sequence C description binding site for residue SF4 A 1201 source : AC1 3) chain A residue 677 type sequence C description binding site for residue SF4 A 1201 source : AC1 4) chain A residue 678 type sequence A description binding site for residue SF4 A 1201 source : AC1 5) chain A residue 763 type sequence C description binding site for residue SF4 A 1201 source : AC1 6) chain A residue 765 type sequence R description binding site for residue SF4 A 1201 source : AC1 7) chain A residue 640 type sequence D description binding site for residue DTP A 1202 source : AC2 8) chain A residue 641 type sequence V description binding site for residue DTP A 1202 source : AC2 9) chain A residue 642 type sequence A description binding site for residue DTP A 1202 source : AC2 10) chain A residue 643 type sequence S description binding site for residue DTP A 1202 source : AC2 11) chain A residue 644 type sequence M description binding site for residue DTP A 1202 source : AC2 12) chain A residue 645 type sequence Y description binding site for residue DTP A 1202 source : AC2 13) chain A residue 781 type sequence R description binding site for residue DTP A 1202 source : AC2 14) chain A residue 785 type sequence K description binding site for residue DTP A 1202 source : AC2 15) chain A residue 824 type sequence K description binding site for residue DTP A 1202 source : AC2 16) chain A residue 828 type sequence N description binding site for residue DTP A 1202 source : AC2 17) chain A residue 877 type sequence D description binding site for residue DTP A 1202 source : AC2 18) chain P residue 11 type sequence X description binding site for residue DTP A 1202 source : AC2 19) chain T residue 5 type sequence T description binding site for residue DTP A 1202 source : AC2 20) chain T residue 6 type sequence G description binding site for residue DTP A 1202 source : AC2 21) chain A residue 640 type sequence D description binding site for residue CA A 1203 source : AC3 22) chain A residue 641 type sequence V description binding site for residue CA A 1203 source : AC3 23) chain A residue 877 type sequence D description binding site for residue CA A 1203 source : AC3

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