|
|
eF-site ID
|
6qhd-ABCD |
|
PDB Code
|
6qhd |
|
Chain
|
A, B, C, D |
|
click to enlarge
|
|
|
Title
|
Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA |
|
Classification
|
TRANSCRIPTION |
|
Compound
|
Signal transducer and activator of transcription 3 |
|
Source
|
(6QHD) |
|
|
Sequence
|
A: |
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFN
YKTLKSQGDSVTRQKMQQLEQMLTALDQMRRSIVSELAGL
LSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLE
NWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPM
LEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ
FTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKF
NILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCASLIVT
EELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNA
WASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFS
STTKRGLSIEQLTTLAEKLLGPYSGCQITWAKFCKENMAG
KGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERA
ILSTKPPGTFLLRFSESSKEGGVTFTWVEQIQSVEPYTKQ
QLNNMSFAEIIMGYLVSPLVYLYPDIPKEEAFGXYCRAPX
LKTKFICVTP
|
| B: |
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFN
YKTLKSQGSVTRQKMQQLEQMLTALDQMRRSIVSELAGLL
SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLEN
WITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPML
EERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQF
TTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFN
ILGTNTKVMNMEESNNGSLSAEFKHLTLREQRASLIVTEE
LHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWA
SILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST
TKRGLSIEQLTTLAEKLLGPYSGCQITWAKFCKENMAGKG
FSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL
STKPPGTFLLRFSESSKEGGVTFTWVETQIQSVEPYTKQQ
LNNMSFAEIIMGYKIILVSPLVYLYPDIPKEEAFGXYCRA
PXLKTKFICVTP
|
| C: |
AAGATTTACGGGAAATGC
|
| D: |
TGCATTTCCCGTAAATCT
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
714 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
2)
|
chain |
B |
| residue |
714 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
3)
|
chain |
A |
| residue |
685 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-acetyllysine; alternate => ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
685 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-acetyllysine; alternate => ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
B |
| residue |
601 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine; alternate => ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
B |
| residue |
615 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine; alternate => ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
601 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine; alternate => ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
615 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine; alternate => ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
A |
| residue |
705 |
| type |
MOD_RES |
| sequence |
X
|
| description |
Phosphotyrosine; by FER and PTK6 => ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:16568091, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:26293184, ECO:0000269|PubMed:31899195, ECO:0000269|PubMed:32929201, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
10)
|
chain |
B |
| residue |
705 |
| type |
MOD_RES |
| sequence |
X
|
| description |
Phosphotyrosine; by FER and PTK6 => ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:16568091, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:26293184, ECO:0000269|PubMed:31899195, ECO:0000269|PubMed:32929201, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
A |
| residue |
707 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
12)
|
chain |
B |
| residue |
707 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000269|PubMed:28065600
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|