eF-site ID 6qg7-A PDB Code 6qg7 Chain A click to enlarge Title Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1k Classification TRANSFERASE Compound Dual specificity mitogen-activated protein kinase kinase 7 Source (MP2K7_HUMAN) Sequence A:  QTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRK TGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQ CFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGK MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCD FGISGRLAGCAAYMAPERIDPIRADVWSLGISLVELATGQ FPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKD CLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMA KT Description (1)  Dual specificity mitogen-activated protein kinase kinase 7 (E.C.2.7.12.2) Functional site 1) chain A residue 143 type sequence G description binding site for residue 6HL A 501 source : AC1 2) chain A residue 163 type sequence A description binding site for residue 6HL A 501 source : AC1 3) chain A residue 165 type sequence K description binding site for residue 6HL A 501 source : AC1 4) chain A residue 182 type sequence D description binding site for residue 6HL A 501 source : AC1 5) chain A residue 212 type sequence M description binding site for residue 6HL A 501 source : AC1 6) chain A residue 213 type sequence E description binding site for residue 6HL A 501 source : AC1 7) chain A residue 215 type sequence M description binding site for residue 6HL A 501 source : AC1 8) chain A residue 218 type sequence C description binding site for residue 6HL A 501 source : AC1 9) chain A residue 221 type sequence K description binding site for residue 6HL A 501 source : AC1 10) chain A residue 263 type sequence S description binding site for residue 6HL A 501 source : AC1 11) chain A residue 255-267 type prosite sequence VIHRDVKPSNILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNILL source prosite : PS00108 12) chain A residue 259 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 165 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 142 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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