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eF-site ID
|
6qfr-A |
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PDB Code
|
6qfr |
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Chain
|
A |
|
click to enlarge
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Title
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Structure of the mitogen activated kinase kinase 7 dfg-out conformation |
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Classification
|
TRANSFERASE |
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Compound
|
Dual specificity mitogen-activated protein kinase kinase 7 |
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Source
|
(MP2K7_HUMAN) |
|
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Sequence
|
A: |
QTGYLTIGGQRYQAEINDLENLGEMQVWKMRFRKTGHVIA
VKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFI
TNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIV
KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGA
YMAPERIIRADVWSLGISLVELATGQFPYKNCKTDFEVLT
KVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNK
LLEHSFIKRYETLEVDVASWFKDVMAKTE
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|
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Description
|
(1) |
Dual specificity mitogen-activated protein kinase kinase 7 (E.C.2.7.12.2)
|
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Functional site
|
|
|
1)
|
chain |
A |
| residue |
259 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
142 |
| type |
BINDING |
| sequence |
M
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
165 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
255-267 |
| type |
prosite |
| sequence |
VIHRDVKPSNILL
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNILL
|
| source |
prosite : PS00108
|
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