eF-site ID 6qfe-B
PDB Code 6qfe
Chain B

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Title Crystal Structure of Human Kallikrein 5 in complex with GSK144
Classification HYDROLASE
Compound Kallikrein-5
Source (KLK5_HUMAN)
Sequence B:  IINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTA
AHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYS
HPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCL
VSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQID
DTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPC
ARPNRPGVYTNLCKFTKWIQETIQANS
Description


Functional site

1) chain B
residue 159
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17881000
source Swiss-Prot : SWS_FT_FI4

2) chain B
residue 18
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3

3) chain B
residue 122
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3

4) chain B
residue 202
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3

5) chain B
residue 57
type ACT_SITE
sequence H
description Charge relay system => ECO:0000269|PubMed:17881000
source Swiss-Prot : SWS_FT_FI1

6) chain B
residue 102
type ACT_SITE
sequence D
description Charge relay system => ECO:0000269|PubMed:17881000
source Swiss-Prot : SWS_FT_FI1

7) chain B
residue 195
type ACT_SITE
sequence S
description Charge relay system => ECO:0000269|PubMed:17881000
source Swiss-Prot : SWS_FT_FI1

8) chain B
residue 99
type SITE
sequence H
description Major binding site for inhibitory zinc
source Swiss-Prot : SWS_FT_FI2


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