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eF-site ID
|
6qd5-A |
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PDB Code
|
6qd5 |
|
Chain
|
A |
|
click to enlarge
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Title
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X-ray Structure of the Human Urea Channel SLC14A1/UT1 |
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Classification
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TRANSPORT PROTEIN |
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Compound
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Urea transporter 1 |
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Source
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(UT1_HUMAN) |
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Sequence
|
A: |
FPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVV
FVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLL
SQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPV
CAMSMTCPIFSSALNSVLSKWDLPVFTLPFNMALSMYLSA
TGHYNPFFPAKLVIPITTAPQISWSDLSALELLKSIPVGV
GQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAA
GLSLSAPFENIYFGLWGFNSSLACIAMGGMFMALTWQTHL
LALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFL
IMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVE
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Description
|
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Functional site
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|
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1)
|
chain |
A |
| residue |
284-304 |
| type |
prosite |
| sequence |
GLWGFNSSLACIAMGGMFMAL
|
| description |
MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GlWgFnSsLAciAmGGMfmaL
|
| source |
prosite : PS00079
|
|
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2)
|
chain |
A |
| residue |
53-73 |
| type |
TRANSMEM |
| sequence |
PVVLQFIDWILRGISQVVFVN
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
A |
| residue |
91-110 |
| type |
TRANSMEM |
| sequence |
WWALTGWLGTVVSTLMALLL
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
116-136 |
| type |
TRANSMEM |
| sequence |
LIASGLYGYNATLVGVLMAVF
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
143-163 |
| type |
TRANSMEM |
| sequence |
FWWLLLPVCAMSMTCPIFSSA
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
A |
| residue |
173-193 |
| type |
TRANSMEM |
| sequence |
LPVFTLPFNMALSMYLSATGH
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
242-262 |
| type |
TRANSMEM |
| sequence |
GGIFLGAILLSSPLMCLHAAI
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
281-301 |
| type |
TRANSMEM |
| sequence |
IYFGLWGFNSSLACIAMGGMF
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
A |
| residue |
310-330 |
| type |
TRANSMEM |
| sequence |
LLALGCALFTAYLGVGMANFM
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
A |
| residue |
333-353 |
| type |
TRANSMEM |
| sequence |
VGLPACTWPFCLATLLFLIMT
|
| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
A |
| residue |
339 |
| type |
SITE |
| sequence |
T
|
| description |
Important for channel permeability => ECO:0000250|UniProtKB:Q5QF96
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
12)
|
chain |
A |
| residue |
211 |
| type |
CARBOHYD |
| sequence |
Q
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|