eF-site ID 6qcz-ABCD PDB Code 6qcz Chain A, B, C, D click to enlarge Title MloK1 model from single particle analysis of 2D crystals, class 3 (intermediate extended conformation) Classification MEMBRANE PROTEIN Compound Cyclic nucleotide-gated potassium channel mll3241 Source (CNGK1_RHILO) Sequence A:  MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLA LAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVL AVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGR VLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFG SIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGI GIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSV SVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLL SLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA B:  MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLA LAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVL AVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGR VLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFG SIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGI GIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSV SVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLL SLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA C:  MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLA LAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVL AVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGR VLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFG SIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGI GIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSV SVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLL SLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA D:  MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLA LAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVL AVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGR VLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFG SIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGI GIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLG PAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSV SVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLL SLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA Description (1)  Cyclic nucleotide-gated potassium channel mll3241 Functional site 1) chain A residue 175 type sequence T description binding site for residue K A 401 source : AC1 2) chain A residue 176 type sequence T description binding site for residue K A 401 source : AC1 3) chain B residue 175 type sequence T description binding site for residue K A 401 source : AC1 4) chain B residue 176 type sequence T description binding site for residue K A 401 source : AC1 5) chain C residue 175 type sequence T description binding site for residue K A 401 source : AC1 6) chain C residue 176 type sequence T description binding site for residue K A 401 source : AC1 7) chain D residue 175 type sequence T description binding site for residue K A 401 source : AC1 8) chain D residue 176 type sequence T description binding site for residue K A 401 source : AC1 9) chain A residue 177 type sequence G description binding site for residue K D 401 source : AC2 10) chain A residue 178 type sequence Y description binding site for residue K D 401 source : AC2 11) chain B residue 177 type sequence G description binding site for residue K D 401 source : AC2 12) chain B residue 178 type sequence Y description binding site for residue K D 401 source : AC2 13) chain C residue 177 type sequence G description binding site for residue K D 401 source : AC2 14) chain C residue 178 type sequence Y description binding site for residue K D 401 source : AC2 15) chain D residue 177 type sequence G description binding site for residue K D 401 source : AC2 16) chain D residue 178 type sequence Y description binding site for residue K D 401 source : AC2 17) chain A residue 262-278 type prosite sequence ICRIGEPGDRMFFVVEG description CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICrIGEpGDrMFFVveG source prosite : PS00888 18) chain A residue 296-313 type prosite sequence FGEMALISGEPRSATVSA description CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALisgep......RSAtVsA source prosite : PS00889 19) chain A residue 1-12 type TOPO_DOM sequence MSVLPFLRIYAP description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 20) chain A residue 62-74 type TOPO_DOM sequence KRRAGVVRDRTPK description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 21) chain A residue 113-129 type TOPO_DOM sequence TFFPVLGRVLANEARNL description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 22) chain A residue 211-355 type TOPO_DOM sequence ATGFYQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRA LRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVEL GPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQML CSSSPEIAEIFRKTALERRGAAASA description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 23) chain B residue 1-12 type TOPO_DOM sequence MSVLPFLRIYAP description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 24) chain B residue 62-74 type TOPO_DOM sequence KRRAGVVRDRTPK description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 25) chain B residue 113-129 type TOPO_DOM sequence TFFPVLGRVLANEARNL description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 26) chain B residue 211-355 type TOPO_DOM sequence ATGFYQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRA LRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVEL GPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQML CSSSPEIAEIFRKTALERRGAAASA description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 27) chain C residue 1-12 type TOPO_DOM sequence MSVLPFLRIYAP description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 28) chain C residue 62-74 type TOPO_DOM sequence KRRAGVVRDRTPK description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 29) chain C residue 113-129 type TOPO_DOM sequence TFFPVLGRVLANEARNL description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 30) chain C residue 211-355 type TOPO_DOM sequence ATGFYQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRA LRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVEL GPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQML CSSSPEIAEIFRKTALERRGAAASA description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 31) chain D residue 1-12 type TOPO_DOM sequence MSVLPFLRIYAP description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 32) chain D residue 62-74 type TOPO_DOM sequence KRRAGVVRDRTPK description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 33) chain D residue 113-129 type TOPO_DOM sequence TFFPVLGRVLANEARNL description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 34) chain D residue 211-355 type TOPO_DOM sequence ATGFYQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRA LRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVEL GPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQML CSSSPEIAEIFRKTALERRGAAASA description Cytoplasmic source Swiss-Prot : SWS_FT_FI1 35) chain A residue 13-30 type TRANSMEM sequence LNAVLAAPGLLAVAALTI description Helical; Name=Segment S1 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 13-30 type TRANSMEM sequence LNAVLAAPGLLAVAALTI description Helical; Name=Segment S1 source Swiss-Prot : SWS_FT_FI2 37) chain C residue 13-30 type TRANSMEM sequence LNAVLAAPGLLAVAALTI description Helical; Name=Segment S1 source Swiss-Prot : SWS_FT_FI2 38) chain D residue 13-30 type TRANSMEM sequence LNAVLAAPGLLAVAALTI description Helical; Name=Segment S1 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 31-38 type TOPO_DOM sequence PDMSGRSR description Periplasmic source Swiss-Prot : SWS_FT_FI3 40) chain A residue 151-161 type TOPO_DOM sequence ERDIQPEKFGS description Periplasmic source Swiss-Prot : SWS_FT_FI3 41) chain A residue 181-185 type TOPO_DOM sequence TIPQS description Periplasmic source Swiss-Prot : SWS_FT_FI3 42) chain B residue 31-38 type TOPO_DOM sequence PDMSGRSR description Periplasmic source Swiss-Prot : SWS_FT_FI3 43) chain B residue 151-161 type TOPO_DOM sequence ERDIQPEKFGS description Periplasmic source Swiss-Prot : SWS_FT_FI3 44) chain B residue 181-185 type TOPO_DOM sequence TIPQS description Periplasmic source Swiss-Prot : SWS_FT_FI3 45) chain C residue 31-38 type TOPO_DOM sequence PDMSGRSR description Periplasmic source Swiss-Prot : SWS_FT_FI3 46) chain C residue 151-161 type TOPO_DOM sequence ERDIQPEKFGS description Periplasmic source Swiss-Prot : SWS_FT_FI3 47) chain C residue 181-185 type TOPO_DOM sequence TIPQS description Periplasmic source Swiss-Prot : SWS_FT_FI3 48) chain D residue 31-38 type TOPO_DOM sequence PDMSGRSR description Periplasmic source Swiss-Prot : SWS_FT_FI3 49) chain D residue 151-161 type TOPO_DOM sequence ERDIQPEKFGS description Periplasmic source Swiss-Prot : SWS_FT_FI3 50) chain D residue 181-185 type TOPO_DOM sequence TIPQS description Periplasmic source Swiss-Prot : SWS_FT_FI3 51) chain A residue 39-61 type TRANSMEM sequence LALAALLAVIWGAYLLQLAATLL description Helical; Name=Segment S2 source Swiss-Prot : SWS_FT_FI4 52) chain B residue 39-61 type TRANSMEM sequence LALAALLAVIWGAYLLQLAATLL description Helical; Name=Segment S2 source Swiss-Prot : SWS_FT_FI4 53) chain C residue 39-61 type TRANSMEM sequence LALAALLAVIWGAYLLQLAATLL description Helical; Name=Segment S2 source Swiss-Prot : SWS_FT_FI4 54) chain D residue 39-61 type TRANSMEM sequence LALAALLAVIWGAYLLQLAATLL description Helical; Name=Segment S2 source Swiss-Prot : SWS_FT_FI4 55) chain A residue 75-94 type TRANSMEM sequence IAIDVLAVLVPLAAFLLDGS description Helical; Name=Segment S3 source Swiss-Prot : SWS_FT_FI5 56) chain B residue 75-94 type TRANSMEM sequence IAIDVLAVLVPLAAFLLDGS description Helical; Name=Segment S3 source Swiss-Prot : SWS_FT_FI5 57) chain C residue 75-94 type TRANSMEM sequence IAIDVLAVLVPLAAFLLDGS description Helical; Name=Segment S3 source Swiss-Prot : SWS_FT_FI5 58) chain D residue 75-94 type TRANSMEM sequence IAIDVLAVLVPLAAFLLDGS description Helical; Name=Segment S3 source Swiss-Prot : SWS_FT_FI5 59) chain A residue 95-112 type TRANSMEM sequence PDWSLYCAVWLLKPLRDS description Helical; Name=Segment S4 source Swiss-Prot : SWS_FT_FI6 60) chain B residue 95-112 type TRANSMEM sequence PDWSLYCAVWLLKPLRDS description Helical; Name=Segment S4 source Swiss-Prot : SWS_FT_FI6 61) chain C residue 95-112 type TRANSMEM sequence PDWSLYCAVWLLKPLRDS description Helical; Name=Segment S4 source Swiss-Prot : SWS_FT_FI6 62) chain D residue 95-112 type TRANSMEM sequence PDWSLYCAVWLLKPLRDS description Helical; Name=Segment S4 source Swiss-Prot : SWS_FT_FI6 63) chain A residue 130-150 type TRANSMEM sequence IGVTTLFGVVLFAVALAAYVI description Helical; Name=Segment S5 source Swiss-Prot : SWS_FT_FI7 64) chain B residue 130-150 type TRANSMEM sequence IGVTTLFGVVLFAVALAAYVI description Helical; Name=Segment S5 source Swiss-Prot : SWS_FT_FI7 65) chain C residue 130-150 type TRANSMEM sequence IGVTTLFGVVLFAVALAAYVI description Helical; Name=Segment S5 source Swiss-Prot : SWS_FT_FI7 66) chain D residue 130-150 type TRANSMEM sequence IGVTTLFGVVLFAVALAAYVI description Helical; Name=Segment S5 source Swiss-Prot : SWS_FT_FI7 67) chain A residue 162-180 type INTRAMEM sequence IPQAMWWAVVTLSTTGYGD description Pore-forming source Swiss-Prot : SWS_FT_FI8 68) chain B residue 162-180 type INTRAMEM sequence IPQAMWWAVVTLSTTGYGD description Pore-forming source Swiss-Prot : SWS_FT_FI8 69) chain C residue 162-180 type INTRAMEM sequence IPQAMWWAVVTLSTTGYGD description Pore-forming source Swiss-Prot : SWS_FT_FI8 70) chain D residue 162-180 type INTRAMEM sequence IPQAMWWAVVTLSTTGYGD description Pore-forming source Swiss-Prot : SWS_FT_FI8 71) chain A residue 186-210 type TRANSMEM sequence FAGRVLAGAVMMSGIGIFGLWAGIL description Helical; Name=Segment S6 source Swiss-Prot : SWS_FT_FI9 72) chain B residue 186-210 type TRANSMEM sequence FAGRVLAGAVMMSGIGIFGLWAGIL description Helical; Name=Segment S6 source Swiss-Prot : SWS_FT_FI9 73) chain C residue 186-210 type TRANSMEM sequence FAGRVLAGAVMMSGIGIFGLWAGIL description Helical; Name=Segment S6 source Swiss-Prot : SWS_FT_FI9 74) chain D residue 186-210 type TRANSMEM sequence FAGRVLAGAVMMSGIGIFGLWAGIL description Helical; Name=Segment S6 source Swiss-Prot : SWS_FT_FI9 75) chain D residue 297 type BINDING sequence G description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 76) chain D residue 307 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 77) chain D residue 348 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 78) chain C residue 348 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 79) chain A residue 348 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 80) chain B residue 297 type BINDING sequence G description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 81) chain B residue 307 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 82) chain B residue 348 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 83) chain C residue 297 type BINDING sequence G description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 84) chain C residue 307 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 85) chain A residue 297 type BINDING sequence G description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10 86) chain A residue 307 type BINDING sequence R description BINDING => ECO:0007744|PDB:1VP6 source Swiss-Prot : SWS_FT_FI10

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