eF-site ID 6qak-D PDB Code 6qak Chain D click to enlarge Title Structure of human ALDH9 in P21212 space group Classification OXIDOREDUCTASE Compound 4-trimethylaminobutyraldehyde dehydrogenase Source (AL9A1_HUMAN) Sequence D:  PMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRV IATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLE AARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEY YAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYP FQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA GVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGGKSPLII FSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRD DMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV FTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKS GFGRENGRVTIEYYSQLKTVCVEMGDVESAF Description Functional site 1) chain D residue 288 type ACT_SITE sequence C description Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008 source Swiss-Prot : SWS_FT_FI2 2) chain D residue 180 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P56533 source Swiss-Prot : SWS_FT_FI3 3) chain D residue 391 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P56533 source Swiss-Prot : SWS_FT_FI3 4) chain D residue 157 type SITE sequence N description Transition state stabilizer => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 5) chain D residue 2 type MOD_RES sequence S description N-acetylserine; in 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed => ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 source Swiss-Prot : SWS_FT_FI5 6) chain D residue 30 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9JLJ2 source Swiss-Prot : SWS_FT_FI6 7) chain D residue 303 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9JLJ2 source Swiss-Prot : SWS_FT_FI6 8) chain D residue 59 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q9JLJ2 source Swiss-Prot : SWS_FT_FI7 9) chain D residue 344 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q9JLJ2 source Swiss-Prot : SWS_FT_FI9 10) chain D residue 298 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI8

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