eF-site/Summary 6qak-B

eF-site ID	6qak-B
PDB Code	6qak
Chain	B

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Title	Structure of human ALDH9 in P21212 space group
Classification	OXIDOREDUCTASE
Compound	4-trimethylaminobutyraldehyde dehydrogenase
Source	(AL9A1_HUMAN)

Sequence	B:	PMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRV IATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLE AARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEY YAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYP FQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA GVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGGKSPLII FSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRD DMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV FTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKS GFGRENGRVTIEYYSQLKTVCVEMGDVESAF

Description

Functional site


1)	chain	B
	residue	217
	type
	sequence	Q
	description	binding site for residue EDO B 501
	source	: AC1

2)	chain	B
	residue	30
	type	MOD_RES
	sequence	K
	description	N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9JLJ2
	source	Swiss-Prot : SWS_FT_FI6

3)	chain	B
	residue	303
	type	MOD_RES
	sequence	K
	description	N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9JLJ2
	source	Swiss-Prot : SWS_FT_FI6

4)	chain	B
	residue	59
	type	MOD_RES
	sequence	K
	description	N6-succinyllysine => ECO:0000250\|UniProtKB:Q9JLJ2
	source	Swiss-Prot : SWS_FT_FI7

5)	chain	B
	residue	298
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI8

6)	chain	B
	residue	344
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0000250\|UniProtKB:Q9JLJ2
	source	Swiss-Prot : SWS_FT_FI9

7)	chain	B
	residue	288
	type	ACT_SITE
	sequence	C
	description	Nucleophile => ECO:0000255\|PROSITE-ProRule:PRU10007, ECO:0000255\|PROSITE-ProRule:PRU10008
	source	Swiss-Prot : SWS_FT_FI2

8)	chain	B
	residue	180
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000250\|UniProtKB:P56533
	source	Swiss-Prot : SWS_FT_FI3

9)	chain	B
	residue	391
	type	BINDING
	sequence	E
	description	BINDING => ECO:0000250\|UniProtKB:P56533
	source	Swiss-Prot : SWS_FT_FI3

10)	chain	B
	residue	157
	type	SITE
	sequence	N
	description	Transition state stabilizer => ECO:0000250
	source	Swiss-Prot : SWS_FT_FI4

11)	chain	B
	residue	2
	type	MOD_RES
	sequence	S
	description	N-acetylserine; in 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed => ECO:0000269\|Ref.7, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378
	source	Swiss-Prot : SWS_FT_FI5