eF-site ID 6q8k-A PDB Code 6q8k Chain A click to enlarge Title CLK1 with bound pyridoquinazoline Classification TRANSFERASE Compound Dual specificity protein kinase CLK1 Source (CLK1_HUMAN) Sequence A:  MHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGR HVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQ MLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIR KMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYN PKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYR APEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKE HLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAG RYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRI TLREALKHPFFDLLKKSI Description (1)  Dual specificity protein kinase CLK1 (E.C.2.7.12.1) Functional site 1) chain A residue 456 type sequence K description binding site for residue EDO A 501 source : AC1 2) chain A residue 466 type sequence I description binding site for residue EDO A 501 source : AC1 3) chain A residue 470 type sequence E description binding site for residue EDO A 501 source : AC1 4) chain A residue 167 type sequence L description binding site for residue FG9 A 502 source : AC2 5) chain A residue 172 type sequence F description binding site for residue FG9 A 502 source : AC2 6) chain A residue 175 type sequence V description binding site for residue FG9 A 502 source : AC2 7) chain A residue 189 type sequence A description binding site for residue FG9 A 502 source : AC2 8) chain A residue 191 type sequence K description binding site for residue FG9 A 502 source : AC2 9) chain A residue 241 type sequence F description binding site for residue FG9 A 502 source : AC2 10) chain A residue 242 type sequence E description binding site for residue FG9 A 502 source : AC2 11) chain A residue 243 type sequence L description binding site for residue FG9 A 502 source : AC2 12) chain A residue 244 type sequence L description binding site for residue FG9 A 502 source : AC2 13) chain A residue 245 type sequence G description binding site for residue FG9 A 502 source : AC2 14) chain A residue 246 type sequence L description binding site for residue FG9 A 502 source : AC2 15) chain A residue 290 type sequence K description binding site for residue FG9 A 502 source : AC2 16) chain A residue 293 type sequence N description binding site for residue FG9 A 502 source : AC2 17) chain A residue 295 type sequence L description binding site for residue FG9 A 502 source : AC2 18) chain A residue 325 type sequence D description binding site for residue FG9 A 502 source : AC2 19) chain A residue 167-191 type prosite sequence LGEGAFGKVVECIDHKAGGRHVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVVeCidhkaggrh.........VAVK source prosite : PS00107 20) chain A residue 284-296 type prosite sequence LTHTDLKPENILF description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LtHtDLKpeNILF source prosite : PS00108 21) chain A residue 288 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 191 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 167 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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