eF-site ID 6q54-B PDB Code 6q54 Chain B click to enlarge Title Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution Classification MEMBRANE PROTEIN Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence B:  GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLA AEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTP IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT YMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLK LNEQGLLDKLKNKWWYDKGECGS Description Functional site 1) chain B residue 183 type sequence K description binding site for residue SO4 A 303 source : AC3 2) chain B residue 21 type sequence K description binding site for residue SO4 A 306 source : AC6 3) chain B residue 22 type sequence N description binding site for residue SO4 A 306 source : AC6 4) chain B residue 26 type sequence L description binding site for residue SO4 A 306 source : AC6 5) chain B residue 149 type sequence R description binding site for residue CIT A 313 source : AD4 6) chain B residue 150 type sequence S description binding site for residue CIT A 313 source : AD4 7) chain B residue 151 type sequence K description binding site for residue CIT A 313 source : AD4 8) chain B residue 156 type sequence D description binding site for residue CIT A 313 source : AD4 9) chain B residue 140 type sequence S description binding site for residue SO4 B 301 source : AD7 10) chain B residue 144 type sequence K description binding site for residue SO4 B 301 source : AD7 11) chain B residue 148 type sequence R description binding site for residue SO4 B 301 source : AD7 12) chain B residue 82 type sequence K description binding site for residue SO4 B 302 source : AD8 13) chain B residue 116 type sequence K description binding site for residue SO4 B 302 source : AD8 14) chain B residue 64 type sequence R description binding site for residue SO4 B 303 source : AD9 15) chain B residue 69 type sequence K description binding site for residue SO4 B 303 source : AD9 16) chain B residue 194 type sequence S description binding site for residue SO4 B 304 source : AE1 17) chain B residue 198 type sequence E description binding site for residue SO4 B 304 source : AE1 18) chain B residue 214 type sequence N description binding site for residue SO4 B 304 source : AE1 19) chain B residue 61 type sequence Y description binding site for residue HJ8 B 305 source : AE2 20) chain B residue 89 type sequence P description binding site for residue HJ8 B 305 source : AE2 21) chain B residue 90 type sequence L description binding site for residue HJ8 B 305 source : AE2 22) chain B residue 91 type sequence T description binding site for residue HJ8 B 305 source : AE2 23) chain B residue 96 type sequence R description binding site for residue HJ8 B 305 source : AE2 24) chain B residue 141 type sequence G description binding site for residue HJ8 B 305 source : AE2 25) chain B residue 142 type sequence S description binding site for residue HJ8 B 305 source : AE2 26) chain B residue 143 type sequence T description binding site for residue HJ8 B 305 source : AE2 27) chain B residue 192 type sequence L description binding site for residue HJ8 B 305 source : AE2 28) chain B residue 193 type sequence E description binding site for residue HJ8 B 305 source : AE2 29) chain B residue 196 type sequence M description binding site for residue HJ8 B 305 source : AE2 30) chain B residue 220 type sequence Y description binding site for residue HJ8 B 305 source : AE2 31) chain B residue 46 type sequence H description binding site for residue GOL B 306 source : AE3 32) chain B residue 240 type sequence K description binding site for residue GOL B 306 source : AE3 33) chain B residue 244 type sequence Q description binding site for residue GOL B 306 source : AE3 34) chain B residue 28 type sequence G description binding site for residue GOL B 307 source : AE4 35) chain B residue 31 type sequence R description binding site for residue GOL B 307 source : AE4 36) chain B residue 52 type sequence K description binding site for residue GOL B 307 source : AE4 37) chain B residue 4 type sequence K description binding site for residue GOL B 308 source : AE5 38) chain B residue 5 type sequence T description binding site for residue GOL B 308 source : AE5 39) chain B residue 19 type sequence M description binding site for residue PGE B 309 source : AE6 40) chain B residue 23 type sequence H description binding site for residue PGE B 309 source : AE6 41) chain B residue 24 type sequence E description binding site for residue PGE B 309 source : AE6 42) chain B residue 31 type sequence R description binding site for residue PGE B 309 source : AE6 43) chain B residue 97 type sequence E description binding site for residue LI B 310 source : AE7 44) chain B residue 100 type sequence I description binding site for residue LI B 310 source : AE7 45) chain B residue 101 type sequence D description binding site for residue LI B 310 source : AE7 46) chain B residue 148 type sequence R description binding site for residue PEG B 311 source : AE8 47) chain B residue 159 type sequence W description binding site for residue PEG B 311 source : AE8 48) chain B residue 163 type sequence R description binding site for residue PEG B 311 source : AE8 49) chain B residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 50) chain B residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 51) chain B residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 52) chain B residue 89 type BINDING sequence P description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 53) chain B residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 54) chain B residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO source Swiss-Prot : SWS_FT_FI1 55) chain B residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 59) chain B residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI4 60) chain B residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI5 61) chain B residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6

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