eF-site ID 6q54-AB PDB Code 6q54 Chain A, B click to enlarge Title Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution Classification MEMBRANE PROTEIN Compound Glutamate receptor 2 Source (GRIA2_RAT) Sequence A:  GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLA AEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTP IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT YMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLK LNEQGLLDKLKNKWWYDKGECGSG B:  GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLA AEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTP IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT YMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLK LNEQGLLDKLKNKWWYDKGECGS Description Functional site 1) chain A residue 139 type sequence D description binding site for residue SO4 A 301 source : AC1 2) chain A residue 140 type sequence S description binding site for residue SO4 A 301 source : AC1 3) chain A residue 144 type sequence K description binding site for residue SO4 A 301 source : AC1 4) chain A residue 148 type sequence R description binding site for residue SO4 A 301 source : AC1 5) chain A residue 194 type sequence S description binding site for residue SO4 A 302 source : AC2 6) chain A residue 198 type sequence E description binding site for residue SO4 A 302 source : AC2 7) chain A residue 214 type sequence N description binding site for residue SO4 A 302 source : AC2 8) chain A residue 31 type sequence R description binding site for residue SO4 A 303 source : AC3 9) chain B residue 183 type sequence K description binding site for residue SO4 A 303 source : AC3 10) chain A residue 45 type sequence K description binding site for residue SO4 A 304 source : AC4 11) chain A residue 46 type sequence H description binding site for residue SO4 A 304 source : AC4 12) chain A residue 244 type sequence Q description binding site for residue SO4 A 304 source : AC4 13) chain A residue 21 type sequence K description binding site for residue SO4 A 305 source : AC5 14) chain A residue 22 type sequence N description binding site for residue SO4 A 305 source : AC5 15) chain A residue 23 type sequence H description binding site for residue SO4 A 305 source : AC5 16) chain A residue 24 type sequence E description binding site for residue SO4 A 305 source : AC5 17) chain A residue 163 type sequence R description binding site for residue SO4 A 306 source : AC6 18) chain A residue 164 type sequence S description binding site for residue SO4 A 306 source : AC6 19) chain B residue 21 type sequence K description binding site for residue SO4 A 306 source : AC6 20) chain B residue 22 type sequence N description binding site for residue SO4 A 306 source : AC6 21) chain B residue 26 type sequence L description binding site for residue SO4 A 306 source : AC6 22) chain A residue 61 type sequence Y description binding site for residue HJ8 A 307 source : AC7 23) chain A residue 89 type sequence P description binding site for residue HJ8 A 307 source : AC7 24) chain A residue 90 type sequence L description binding site for residue HJ8 A 307 source : AC7 25) chain A residue 91 type sequence T description binding site for residue HJ8 A 307 source : AC7 26) chain A residue 96 type sequence R description binding site for residue HJ8 A 307 source : AC7 27) chain A residue 141 type sequence G description binding site for residue HJ8 A 307 source : AC7 28) chain A residue 142 type sequence S description binding site for residue HJ8 A 307 source : AC7 29) chain A residue 143 type sequence T description binding site for residue HJ8 A 307 source : AC7 30) chain A residue 192 type sequence L description binding site for residue HJ8 A 307 source : AC7 31) chain A residue 193 type sequence E description binding site for residue HJ8 A 307 source : AC7 32) chain A residue 196 type sequence M description binding site for residue HJ8 A 307 source : AC7 33) chain A residue 220 type sequence Y description binding site for residue HJ8 A 307 source : AC7 34) chain A residue 27 type sequence E description binding site for residue GOL A 308 source : AC8 35) chain A residue 28 type sequence G description binding site for residue GOL A 308 source : AC8 36) chain A residue 29 type sequence N description binding site for residue GOL A 308 source : AC8 37) chain A residue 30 type sequence E description binding site for residue GOL A 308 source : AC8 38) chain A residue 144 type sequence K description binding site for residue PGE A 309 source : AC9 39) chain A residue 148 type sequence R description binding site for residue PGE A 309 source : AC9 40) chain A residue 159 type sequence W description binding site for residue PGE A 309 source : AC9 41) chain A residue 163 type sequence R description binding site for residue PGE A 309 source : AC9 42) chain A residue 153 type sequence A description binding site for residue CL A 310 source : AD1 43) chain A residue 123 type sequence S description binding site for residue CL A 311 source : AD2 44) chain A residue 124 type sequence A description binding site for residue CL A 311 source : AD2 45) chain A residue 252 type sequence N description binding site for residue CL A 312 source : AD3 46) chain A residue 176 type sequence E description binding site for residue CIT A 313 source : AD4 47) chain A residue 183 type sequence K description binding site for residue CIT A 313 source : AD4 48) chain B residue 149 type sequence R description binding site for residue CIT A 313 source : AD4 49) chain B residue 150 type sequence S description binding site for residue CIT A 313 source : AD4 50) chain B residue 151 type sequence K description binding site for residue CIT A 313 source : AD4 51) chain B residue 156 type sequence D description binding site for residue CIT A 313 source : AD4 52) chain A residue 2 type sequence A description binding site for residue LI A 314 source : AD5 53) chain A residue 5 type sequence T description binding site for residue LI A 314 source : AD5 54) chain A residue 97 type sequence E description binding site for residue LI A 315 source : AD6 55) chain A residue 100 type sequence I description binding site for residue LI A 315 source : AD6 56) chain A residue 101 type sequence D description binding site for residue LI A 315 source : AD6 57) chain B residue 140 type sequence S description binding site for residue SO4 B 301 source : AD7 58) chain B residue 144 type sequence K description binding site for residue SO4 B 301 source : AD7 59) chain B residue 148 type sequence R description binding site for residue SO4 B 301 source : AD7 60) chain B residue 82 type sequence K description binding site for residue SO4 B 302 source : AD8 61) chain B residue 116 type sequence K description binding site for residue SO4 B 302 source : AD8 62) chain B residue 64 type sequence R description binding site for residue SO4 B 303 source : AD9 63) chain B residue 69 type sequence K description binding site for residue SO4 B 303 source : AD9 64) chain B residue 194 type sequence S description binding site for residue SO4 B 304 source : AE1 65) chain B residue 198 type sequence E description binding site for residue SO4 B 304 source : AE1 66) chain B residue 214 type sequence N description binding site for residue SO4 B 304 source : AE1 67) chain B residue 61 type sequence Y description binding site for residue HJ8 B 305 source : AE2 68) chain B residue 89 type sequence P description binding site for residue HJ8 B 305 source : AE2 69) chain B residue 90 type sequence L description binding site for residue HJ8 B 305 source : AE2 70) chain B residue 91 type sequence T description binding site for residue HJ8 B 305 source : AE2 71) chain B residue 96 type sequence R description binding site for residue HJ8 B 305 source : AE2 72) chain B residue 141 type sequence G description binding site for residue HJ8 B 305 source : AE2 73) chain B residue 142 type sequence S description binding site for residue HJ8 B 305 source : AE2 74) chain B residue 143 type sequence T description binding site for residue HJ8 B 305 source : AE2 75) chain B residue 192 type sequence L description binding site for residue HJ8 B 305 source : AE2 76) chain B residue 193 type sequence E description binding site for residue HJ8 B 305 source : AE2 77) chain B residue 196 type sequence M description binding site for residue HJ8 B 305 source : AE2 78) chain B residue 220 type sequence Y description binding site for residue HJ8 B 305 source : AE2 79) chain B residue 46 type sequence H description binding site for residue GOL B 306 source : AE3 80) chain B residue 240 type sequence K description binding site for residue GOL B 306 source : AE3 81) chain B residue 244 type sequence Q description binding site for residue GOL B 306 source : AE3 82) chain A residue 3 type sequence N description binding site for residue GOL B 307 source : AE4 83) chain B residue 28 type sequence G description binding site for residue GOL B 307 source : AE4 84) chain B residue 31 type sequence R description binding site for residue GOL B 307 source : AE4 85) chain B residue 52 type sequence K description binding site for residue GOL B 307 source : AE4 86) chain B residue 4 type sequence K description binding site for residue GOL B 308 source : AE5 87) chain B residue 5 type sequence T description binding site for residue GOL B 308 source : AE5 88) chain A residue 3 type sequence N description binding site for residue PGE B 309 source : AE6 89) chain A residue 258 type sequence K description binding site for residue PGE B 309 source : AE6 90) chain A residue 260 type sequence E description binding site for residue PGE B 309 source : AE6 91) chain B residue 19 type sequence M description binding site for residue PGE B 309 source : AE6 92) chain B residue 23 type sequence H description binding site for residue PGE B 309 source : AE6 93) chain B residue 24 type sequence E description binding site for residue PGE B 309 source : AE6 94) chain B residue 31 type sequence R description binding site for residue PGE B 309 source : AE6 95) chain B residue 97 type sequence E description binding site for residue LI B 310 source : AE7 96) chain B residue 100 type sequence I description binding site for residue LI B 310 source : AE7 97) chain B residue 101 type sequence D description binding site for residue LI B 310 source : AE7 98) chain B residue 148 type sequence R description binding site for residue PEG B 311 source : AE8 99) chain B residue 159 type sequence W description binding site for residue PEG B 311 source : AE8 100) chain B residue 163 type sequence R description binding site for residue PEG B 311 source : AE8 101) chain A residue 61 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 102) chain A residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 103) chain A residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 104) chain B residue 61 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 105) chain B residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 106) chain B residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16483599 source Swiss-Prot : SWS_FT_FI1 107) chain A residue 89 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 108) chain B residue 89 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 109) chain A residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 110) chain A residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 111) chain A residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 112) chain B residue 64 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 113) chain B residue 148 type SITE sequence R description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 114) chain B residue 240 type SITE sequence K description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI4 115) chain A residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI5 116) chain B residue 121 type SITE sequence I description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI5 117) chain A residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI6 118) chain B residue 150 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI6 119) chain A residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI7 120) chain B residue 184 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 source Swiss-Prot : SWS_FT_FI7 121) chain A residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 122) chain B residue 3 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 123) chain A residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 124) chain A residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 125) chain A residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 126) chain B residue 91 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 127) chain B residue 142 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3 128) chain B residue 143 type BINDING sequence T description BINDING => ECO:0000269|PubMed:25103405 source Swiss-Prot : SWS_FT_FI3

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