eF-site ID 6q54-A
PDB Code 6q54
Chain A

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Title Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution
Classification MEMBRANE PROTEIN
Compound Glutamate receptor 2
Source (GRIA2_RAT)
Sequence A:  GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLA
AEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY
GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTP
IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT
YMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLK
LNEQGLLDKLKNKWWYDKGECGSG
Description


Functional site

1) chain A
residue 139
type
sequence D
description binding site for residue SO4 A 301
source : AC1

2) chain A
residue 140
type
sequence S
description binding site for residue SO4 A 301
source : AC1

3) chain A
residue 144
type
sequence K
description binding site for residue SO4 A 301
source : AC1

4) chain A
residue 148
type
sequence R
description binding site for residue SO4 A 301
source : AC1

5) chain A
residue 194
type
sequence S
description binding site for residue SO4 A 302
source : AC2

6) chain A
residue 198
type
sequence E
description binding site for residue SO4 A 302
source : AC2

7) chain A
residue 214
type
sequence N
description binding site for residue SO4 A 302
source : AC2

8) chain A
residue 31
type
sequence R
description binding site for residue SO4 A 303
source : AC3

9) chain A
residue 45
type
sequence K
description binding site for residue SO4 A 304
source : AC4

10) chain A
residue 46
type
sequence H
description binding site for residue SO4 A 304
source : AC4

11) chain A
residue 244
type
sequence Q
description binding site for residue SO4 A 304
source : AC4

12) chain A
residue 21
type
sequence K
description binding site for residue SO4 A 305
source : AC5

13) chain A
residue 22
type
sequence N
description binding site for residue SO4 A 305
source : AC5

14) chain A
residue 23
type
sequence H
description binding site for residue SO4 A 305
source : AC5

15) chain A
residue 24
type
sequence E
description binding site for residue SO4 A 305
source : AC5

16) chain A
residue 163
type
sequence R
description binding site for residue SO4 A 306
source : AC6

17) chain A
residue 164
type
sequence S
description binding site for residue SO4 A 306
source : AC6

18) chain A
residue 61
type
sequence Y
description binding site for residue HJ8 A 307
source : AC7

19) chain A
residue 89
type
sequence P
description binding site for residue HJ8 A 307
source : AC7

20) chain A
residue 90
type
sequence L
description binding site for residue HJ8 A 307
source : AC7

21) chain A
residue 91
type
sequence T
description binding site for residue HJ8 A 307
source : AC7

22) chain A
residue 96
type
sequence R
description binding site for residue HJ8 A 307
source : AC7

23) chain A
residue 141
type
sequence G
description binding site for residue HJ8 A 307
source : AC7

24) chain A
residue 142
type
sequence S
description binding site for residue HJ8 A 307
source : AC7

25) chain A
residue 143
type
sequence T
description binding site for residue HJ8 A 307
source : AC7

26) chain A
residue 192
type
sequence L
description binding site for residue HJ8 A 307
source : AC7

27) chain A
residue 193
type
sequence E
description binding site for residue HJ8 A 307
source : AC7

28) chain A
residue 196
type
sequence M
description binding site for residue HJ8 A 307
source : AC7

29) chain A
residue 220
type
sequence Y
description binding site for residue HJ8 A 307
source : AC7

30) chain A
residue 27
type
sequence E
description binding site for residue GOL A 308
source : AC8

31) chain A
residue 28
type
sequence G
description binding site for residue GOL A 308
source : AC8

32) chain A
residue 29
type
sequence N
description binding site for residue GOL A 308
source : AC8

33) chain A
residue 30
type
sequence E
description binding site for residue GOL A 308
source : AC8

34) chain A
residue 144
type
sequence K
description binding site for residue PGE A 309
source : AC9

35) chain A
residue 148
type
sequence R
description binding site for residue PGE A 309
source : AC9

36) chain A
residue 159
type
sequence W
description binding site for residue PGE A 309
source : AC9

37) chain A
residue 163
type
sequence R
description binding site for residue PGE A 309
source : AC9

38) chain A
residue 153
type
sequence A
description binding site for residue CL A 310
source : AD1

39) chain A
residue 123
type
sequence S
description binding site for residue CL A 311
source : AD2

40) chain A
residue 124
type
sequence A
description binding site for residue CL A 311
source : AD2

41) chain A
residue 252
type
sequence N
description binding site for residue CL A 312
source : AD3

42) chain A
residue 176
type
sequence E
description binding site for residue CIT A 313
source : AD4

43) chain A
residue 183
type
sequence K
description binding site for residue CIT A 313
source : AD4

44) chain A
residue 2
type
sequence A
description binding site for residue LI A 314
source : AD5

45) chain A
residue 5
type
sequence T
description binding site for residue LI A 314
source : AD5

46) chain A
residue 97
type
sequence E
description binding site for residue LI A 315
source : AD6

47) chain A
residue 100
type
sequence I
description binding site for residue LI A 315
source : AD6

48) chain A
residue 101
type
sequence D
description binding site for residue LI A 315
source : AD6

49) chain A
residue 3
type
sequence N
description binding site for residue GOL B 307
source : AE4

50) chain A
residue 3
type
sequence N
description binding site for residue PGE B 309
source : AE6

51) chain A
residue 258
type
sequence K
description binding site for residue PGE B 309
source : AE6

52) chain A
residue 260
type
sequence E
description binding site for residue PGE B 309
source : AE6

53) chain A
residue 61
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:16483599
source Swiss-Prot : SWS_FT_FI1

54) chain A
residue 96
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:16483599
source Swiss-Prot : SWS_FT_FI1

55) chain A
residue 193
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:16483599
source Swiss-Prot : SWS_FT_FI1

56) chain A
residue 89
type BINDING
sequence P
description
source Swiss-Prot : SWS_FT_FI2

57) chain A
residue 64
type SITE
sequence R
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI4

58) chain A
residue 148
type SITE
sequence R
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI4

59) chain A
residue 240
type SITE
sequence K
description Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI4

60) chain A
residue 121
type SITE
sequence I
description Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI5

61) chain A
residue 150
type MOD_RES
sequence S
description Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
source Swiss-Prot : SWS_FT_FI6

62) chain A
residue 184
type MOD_RES
sequence S
description Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
source Swiss-Prot : SWS_FT_FI7

63) chain A
residue 3
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI8

64) chain A
residue 91
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI3

65) chain A
residue 142
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI3

66) chain A
residue 143
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:25103405
source Swiss-Prot : SWS_FT_FI3


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