eF-site ID 6pnw-AB PDB Code 6pnw Chain A, B click to enlarge Title X-RAY STRUCTURE OF ERABUTOXIN C, A DIMERIC NEUROTOXIN Classification TOXIN Compound Erabutoxin c Source ORGANISM_COMMON: Black-banded sea krait; ORGANISM_SCIENTIFIC: Laticauda semifasciata; Sequence A:  RICFNHQSSQPQTTKTCSPGESSCYHKQWSDFRGTIIERG CGCPTVKPGINLSCCESEVCNN B:  RICFNHQSSQPQTTKTCSPGESSCYHKQWSDFRGTIIERG CGCPTVKPGINLSCCESEVCNN Description Functional site 1) chain A residue 25 type sequence Y description source : RCT 2) chain A residue 27 type sequence K description source : RCT 3) chain A residue 29 type sequence W description source : RCT 4) chain A residue 31 type sequence D description source : RCT 5) chain A residue 32 type sequence F description source : RCT 6) chain A residue 33 type sequence R description source : RCT 7) chain A residue 34 type sequence G description source : RCT 8) chain A residue 36 type sequence I description source : RCT 9) chain A residue 38 type sequence E description source : RCT 10) chain A residue 40 type sequence G description source : RCT 11) chain A residue 41 type sequence C description source : RCT 12) chain A residue 42 type sequence G description source : RCT 13) chain A residue 43 type sequence C description source : RCT 14) chain A residue 44 type sequence P description source : RCT 15) chain A residue 46 type sequence V description source : RCT 16) chain A residue 47 type sequence K description source : RCT 17) chain A residue 49 type sequence G description source : RCT 18) chain A residue 50 type sequence I description source : RCT 19) chain A residue 52 type sequence L description source : RCT 20) chain A residue 54 type sequence C description source : RCT 21) chain A residue 40-58 type prosite sequence GCGCPTVKPGINLSCCESE description SNAKE_TOXIN Snake toxins signature. GCg..CPtvkpginls.CCesE source prosite : PS00272 22) chain A residue 6 type SITE sequence H description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 9 type SITE sequence S description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 25 type SITE sequence Y description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 32 type SITE sequence F description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 34 type SITE sequence G description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 6 type SITE sequence H description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 9 type SITE sequence S description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 25 type SITE sequence Y description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 32 type SITE sequence F description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 34 type SITE sequence G description Moderately important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 7 type SITE sequence Q description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 29 type SITE sequence W description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 31 type SITE sequence D description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 36 type SITE sequence I description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 38 type SITE sequence E description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 47 type SITE sequence K description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 7 type SITE sequence Q description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 29 type SITE sequence W description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 31 type SITE sequence D description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 36 type SITE sequence I description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 38 type SITE sequence E description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 47 type SITE sequence K description Very important residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 8 type SITE sequence S description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3 45) chain A residue 10 type SITE sequence Q description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3 46) chain A residue 27 type SITE sequence K description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3 47) chain A residue 33 type SITE sequence R description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3 48) chain B residue 8 type SITE sequence S description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3 49) chain B residue 10 type SITE sequence Q description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3 50) chain B residue 27 type SITE sequence K description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3 51) chain B residue 33 type SITE sequence R description Key residue for binding to acetylcholine receptor => ECO:0000250|UniProtKB:P60775 source Swiss-Prot : SWS_FT_FI3

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