eF-site ID 6pet-C PDB Code 6pet Chain C click to enlarge Title Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha Classification NUCLEAR PROTEIN Compound Estrogen receptor Source (ESR1_HUMAN) Sequence C:  LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGL LTNLADRELVHMINWAKRVPGFVDLTSHDQVHLLECAWLE ILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIF DMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKS LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL LILSHIRHMSNKGMEHLYSMKCKNVVPSYDLLLEMLDAH Description Functional site 1) chain C residue 346 type sequence L description binding site for residue G9J C 601 source : AC3 2) chain C residue 347 type sequence T description binding site for residue G9J C 601 source : AC3 3) chain C residue 350 type sequence A description binding site for residue G9J C 601 source : AC3 4) chain C residue 353 type sequence E description binding site for residue G9J C 601 source : AC3 5) chain C residue 387 type sequence L description binding site for residue G9J C 601 source : AC3 6) chain C residue 394 type sequence R description binding site for residue G9J C 601 source : AC3 7) chain C residue 404 type sequence F description binding site for residue G9J C 601 source : AC3 8) chain C residue 421 type sequence M description binding site for residue G9J C 601 source : AC3 9) chain C residue 424 type sequence I description binding site for residue G9J C 601 source : AC3 10) chain C residue 524 type sequence H description binding site for residue G9J C 601 source : AC3 11) chain C residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 12) chain C residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 13) chain C residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 14) chain C residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 15) chain C residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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