eF-site ID 6pet-A PDB Code 6pet Chain A click to enlarge Title Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha Classification NUCLEAR PROTEIN Compound Estrogen receptor Source (ESR1_HUMAN) Sequence A:  LALSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELV HMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRS MEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRF RMMNLQGEEFVCLKSIILLNSGVYTTLKSLEEKDHIHRVL DKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN KGMEHLYVVPSYDLLLEMLD Description Functional site 1) chain A residue 346 type sequence L description binding site for residue ODY A 601 source : AC2 2) chain A residue 349 type sequence L description binding site for residue ODY A 601 source : AC2 3) chain A residue 350 type sequence A description binding site for residue ODY A 601 source : AC2 4) chain A residue 351 type sequence D description binding site for residue ODY A 601 source : AC2 5) chain A residue 353 type sequence E description binding site for residue ODY A 601 source : AC2 6) chain A residue 383 type sequence W description binding site for residue ODY A 601 source : AC2 7) chain A residue 421 type sequence M description binding site for residue ODY A 601 source : AC2 8) chain A residue 424 type sequence I description binding site for residue ODY A 601 source : AC2 9) chain A residue 521 type sequence G description binding site for residue ODY A 601 source : AC2 10) chain A residue 524 type sequence H description binding site for residue ODY A 601 source : AC2 11) chain A residue 525 type sequence L description binding site for residue ODY A 601 source : AC2 12) chain A residue 533 type sequence V description binding site for residue ODY A 601 source : AC2 13) chain A residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 14) chain A residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 15) chain A residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 16) chain A residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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