eF-site ID 6pdo-AB
PDB Code 6pdo
Chain A, B

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Title Human PIM1 bound to benzothiophene inhibitor 354
Classification TRANSFERASE/TRANSFERASE Inhibitor
Compound Serine/threonine-protein kinase pim-1
Source (6PDO)
Sequence A:  ESQYQVGPLLGSSVYSGIRVSDNLPVAIKHVEKDRISDWG
ELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVL
ILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC
HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY
TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG
DIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDR
PTFEEIQNHPWMQDVLLPQETAEIHLH
B:  RKRRRHPS
Description


Functional site

1) chain A
residue 65
type
sequence A
description binding site for residue OD1 A 501
source : AC1

2) chain A
residue 67
type
sequence K
description binding site for residue OD1 A 501
source : AC1

3) chain A
residue 121
type
sequence E
description binding site for residue OD1 A 501
source : AC1

4) chain A
residue 131
type
sequence D
description binding site for residue OD1 A 501
source : AC1

5) chain A
residue 174
type
sequence L
description binding site for residue OD1 A 501
source : AC1

6) chain A
residue 185
type
sequence I
description binding site for residue OD1 A 501
source : AC1

7) chain A
residue 186
type
sequence D
description binding site for residue OD1 A 501
source : AC1

8) chain A
residue 167
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

9) chain A
residue 44
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 67
type BINDING
sequence K
description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862
source Swiss-Prot : SWS_FT_FI3

11) chain A
residue 121
type BINDING
sequence E
description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862
source Swiss-Prot : SWS_FT_FI3

12) chain A
residue 128
type BINDING
sequence D
description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862
source Swiss-Prot : SWS_FT_FI3

13) chain A
residue 44-67
type prosite
sequence LGSSVYSGIRVSDNLPVAIK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK
source prosite : PS00107

14) chain A
residue 163-175
type prosite
sequence VLHRDIKDENILI
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI
source prosite : PS00108

15) chain A
residue 98
type MOD_RES
sequence S
description Phosphoserine => ECO:0000269|PubMed:15657054
source Swiss-Prot : SWS_FT_FI6

16) chain A
residue 261
type MOD_RES
sequence S
description Phosphoserine => ECO:0000269|PubMed:15657054
source Swiss-Prot : SWS_FT_FI6


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