eF-site ID 6pbf-ABCD
PDB Code 6pbf
Chain A, B, C, D
Title ZINC9155420-bound TRPV5 in nanodiscs
Classification TRANSPORT PROTEIN
Compound Transient receptor potential cation channel subfamily V member 5
Source (TRPV5_RABIT)
Sequence A:  WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLFQQ
RGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEP
FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRR
SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDS
LGNTVLHILILQPNKTFACQMYNLLLSYDEQSLELVPNHQ
GLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYD
LTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSF
KWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNR
TDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVII
LLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLT
MVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFT
IMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNN
LGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITY
AAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVA
TTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHH
B:  WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLFQQ
RGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEP
FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRR
SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDS
LGNTVLHILILQPNKTFACQMYNLLLSYDEQSLELVPNHQ
GLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYD
LTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSF
KWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNR
TDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVII
LLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLT
MVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFT
IMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNN
LGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITY
AAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVA
TTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHH
C:  WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLFQQ
RGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEP
FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRR
SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDS
LGNTVLHILILQPNKTFACQMYNLLLSYDEQSLELVPNHQ
GLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYD
LTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSF
KWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNR
TDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVII
LLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLT
MVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFT
IMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNN
LGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITY
AAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVA
TTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHH
D:  WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLFQQ
RGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEP
FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRR
SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDS
LGNTVLHILILQPNKTFACQMYNLLLSYDEQSLELVPNHQ
GLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYD
LTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSF
KWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNR
TDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVII
LLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLT
MVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFT
IMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNN
LGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITY
AAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVA
TTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHH
Description


Functional site
1) chain A
residue 491
type
sequence M
description binding site for residue O6V A 1001
source : AC1
2) chain A
residue 494
type
sequence C
description binding site for residue O6V A 1001
source : AC1
3) chain C
residue 564
type
sequence I
description binding site for residue O6V A 1001
source : AC1
4) chain A
residue 564
type
sequence I
description binding site for residue O6V A 1002
source : AC2
5) chain B
residue 491
type
sequence M
description binding site for residue O6V A 1002
source : AC2
6) chain B
residue 494
type
sequence C
description binding site for residue O6V A 1002
source : AC2
7) chain B
residue 564
type
sequence I
description binding site for residue O6V B 1001
source : AC3
8) chain D
residue 491
type
sequence M
description binding site for residue O6V B 1001
source : AC3
9) chain D
residue 494
type
sequence C
description binding site for residue O6V B 1001
source : AC3
10) chain C
residue 491
type
sequence M
description binding site for residue O6V C 1001
source : AC4
11) chain C
residue 494
type
sequence C
description binding site for residue O6V C 1001
source : AC4
12) chain D
residue 564
type
sequence I
description binding site for residue O6V C 1001
source : AC4
13) chain A
residue 409-419
type TOPO_DOM
sequence RVGASRYFGQT
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
14) chain A
residue 470-492
type TOPO_DOM
sequence RGFQMLGPFTIMIQKMIFGDLMR
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
15) chain B
residue 409-419
type TOPO_DOM
sequence RVGASRYFGQT
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
16) chain B
residue 470-492
type TOPO_DOM
sequence RGFQMLGPFTIMIQKMIFGDLMR
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
17) chain C
residue 409-419
type TOPO_DOM
sequence RVGASRYFGQT
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
18) chain C
residue 470-492
type TOPO_DOM
sequence RGFQMLGPFTIMIQKMIFGDLMR
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
19) chain D
residue 409-419
type TOPO_DOM
sequence RVGASRYFGQT
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
20) chain D
residue 470-492
type TOPO_DOM
sequence RGFQMLGPFTIMIQKMIFGDLMR
description Cytoplasmic => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI1
21) chain C
residue 557-577
type TRANSMEM
sequence ITYAAFAIIATLLMLNLFIAM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
22) chain A
residue 328-348
type TRANSMEM
sequence YFCVLASLYILYMICFTTCCI
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
23) chain A
residue 386-408
type TRANSMEM
sequence LVGELVTVTGAVIILLLEIPDIF
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
24) chain A
residue 420-442
type TRANSMEM
sequence ILGGPFHVIIITYASLVLLTMVM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
25) chain A
residue 449-469
type TRANSMEM
sequence GEVVPLSFALVLGWCSVMYFA
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
26) chain A
residue 493-513
type TRANSMEM
sequence FCWLMAVVILGFASAFHITFQ
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
27) chain A
residue 557-577
type TRANSMEM
sequence ITYAAFAIIATLLMLNLFIAM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
28) chain B
residue 328-348
type TRANSMEM
sequence YFCVLASLYILYMICFTTCCI
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
29) chain B
residue 386-408
type TRANSMEM
sequence LVGELVTVTGAVIILLLEIPDIF
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
30) chain B
residue 420-442
type TRANSMEM
sequence ILGGPFHVIIITYASLVLLTMVM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
31) chain B
residue 449-469
type TRANSMEM
sequence GEVVPLSFALVLGWCSVMYFA
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
32) chain B
residue 493-513
type TRANSMEM
sequence FCWLMAVVILGFASAFHITFQ
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
33) chain B
residue 557-577
type TRANSMEM
sequence ITYAAFAIIATLLMLNLFIAM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
34) chain C
residue 328-348
type TRANSMEM
sequence YFCVLASLYILYMICFTTCCI
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
35) chain C
residue 386-408
type TRANSMEM
sequence LVGELVTVTGAVIILLLEIPDIF
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
36) chain C
residue 420-442
type TRANSMEM
sequence ILGGPFHVIIITYASLVLLTMVM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
37) chain C
residue 449-469
type TRANSMEM
sequence GEVVPLSFALVLGWCSVMYFA
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
38) chain C
residue 493-513
type TRANSMEM
sequence FCWLMAVVILGFASAFHITFQ
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
39) chain D
residue 328-348
type TRANSMEM
sequence YFCVLASLYILYMICFTTCCI
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
40) chain D
residue 386-408
type TRANSMEM
sequence LVGELVTVTGAVIILLLEIPDIF
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
41) chain D
residue 420-442
type TRANSMEM
sequence ILGGPFHVIIITYASLVLLTMVM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
42) chain D
residue 449-469
type TRANSMEM
sequence GEVVPLSFALVLGWCSVMYFA
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
43) chain D
residue 493-513
type TRANSMEM
sequence FCWLMAVVILGFASAFHITFQ
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
44) chain D
residue 557-577
type TRANSMEM
sequence ITYAAFAIIATLLMLNLFIAM
description Helical => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI2
45) chain A
residue 349-385
type TOPO_DOM
sequence YRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIR
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
46) chain A
residue 443-448
type TOPO_DOM
sequence RLTNMN
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
47) chain B
residue 349-385
type TOPO_DOM
sequence YRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIR
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
48) chain B
residue 443-448
type TOPO_DOM
sequence RLTNMN
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
49) chain C
residue 349-385
type TOPO_DOM
sequence YRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIR
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
50) chain C
residue 443-448
type TOPO_DOM
sequence RLTNMN
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
51) chain D
residue 349-385
type TOPO_DOM
sequence YRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIR
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
52) chain D
residue 443-448
type TOPO_DOM
sequence RLTNMN
description Extracellular => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI3
53) chain A
residue 524-544
type INTRAMEM
sequence SDYPTALFSTFELFLTIIDGP
description Pore-forming => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI4
54) chain B
residue 524-544
type INTRAMEM
sequence SDYPTALFSTFELFLTIIDGP
description Pore-forming => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI4
55) chain C
residue 524-544
type INTRAMEM
sequence SDYPTALFSTFELFLTIIDGP
description Pore-forming => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI4
56) chain D
residue 524-544
type INTRAMEM
sequence SDYPTALFSTFELFLTIIDGP
description Pore-forming => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI4
57) chain A
residue 542
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI5
58) chain B
residue 542
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI5
59) chain C
residue 542
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI5
60) chain D
residue 542
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:29323279
source Swiss-Prot : SWS_FT_FI5
61) chain A
residue 358
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI8
62) chain B
residue 358
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI8
63) chain C
residue 358
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI8
64) chain D
residue 358
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI8

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