eF-site ID 6pbf-A PDB Code 6pbf Chain A click to enlarge Title ZINC9155420-bound TRPV5 in nanodiscs Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 5 Source (TRPV5_RABIT) Sequence A:  WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLFQQ RGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEP FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRR SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDS LGNTVLHILILQPNKTFACQMYNLLLSYDEQSLELVPNHQ GLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYD LTEIDSWGEELSFLELVVSSKKREARQILEQTPVKELVSF KWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNR TDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVII LLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLT MVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFT IMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNN LGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITY AAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVA TTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHH Description Functional site 1) chain A residue 491 type sequence M description binding site for residue O6V A 1001 source : AC1 2) chain A residue 494 type sequence C description binding site for residue O6V A 1001 source : AC1 3) chain A residue 564 type sequence I description binding site for residue O6V A 1002 source : AC2 4) chain A residue 409-419 type TOPO_DOM sequence RVGASRYFGQT description Cytoplasmic => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 470-492 type TOPO_DOM sequence RGFQMLGPFTIMIQKMIFGDLMR description Cytoplasmic => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 328-348 type TRANSMEM sequence YFCVLASLYILYMICFTTCCI description Helical => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 386-408 type TRANSMEM sequence LVGELVTVTGAVIILLLEIPDIF description Helical => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 420-442 type TRANSMEM sequence ILGGPFHVIIITYASLVLLTMVM description Helical => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 449-469 type TRANSMEM sequence GEVVPLSFALVLGWCSVMYFA description Helical => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 493-513 type TRANSMEM sequence FCWLMAVVILGFASAFHITFQ description Helical => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 557-577 type TRANSMEM sequence ITYAAFAIIATLLMLNLFIAM description Helical => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 349-385 type TOPO_DOM sequence YRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIR description Extracellular => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 443-448 type TOPO_DOM sequence RLTNMN description Extracellular => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 524-544 type INTRAMEM sequence SDYPTALFSTFELFLTIIDGP description Pore-forming => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 358 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 16) chain A residue 542 type BINDING sequence D description BINDING => ECO:0000269|PubMed:29323279 source Swiss-Prot : SWS_FT_FI5

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